Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy
Abstract Background Here, we aimed to assess the specific features of lung cancer in patients with long‐term oxygen therapy (LTOT), and compare their outcomes with patients suffering from lung cancer without LTOT. Methods This retrospective, case‐controlled study included patients with LTOT and an i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14692 |
| _version_ | 1828076093858381824 |
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| author | Timothée Lambert Kinan El Husseini Maeva Zysman Boris Duchemann André Gillibert Luca Campedel Edouard Dantoing Camille Rolland‐Debord Maxime Patout |
| author_facet | Timothée Lambert Kinan El Husseini Maeva Zysman Boris Duchemann André Gillibert Luca Campedel Edouard Dantoing Camille Rolland‐Debord Maxime Patout |
| author_sort | Timothée Lambert |
| collection | DOAJ |
| description | Abstract Background Here, we aimed to assess the specific features of lung cancer in patients with long‐term oxygen therapy (LTOT), and compare their outcomes with patients suffering from lung cancer without LTOT. Methods This retrospective, case‐controlled study included patients with LTOT and an incident diagnosis of lung cancer treated at Rouen University Hospital. Results Out of 2201 patients with LTOT, 31 were diagnosed with lung cancer. Among 24 patients with proven lung cancer, the most frequent histological type was squamous cell carcinoma (n = 12/24, 50%). Active treatment of any type was given in 19/31 (61%) and 41/62 (66%) of patients in the LTOT and control groups, respectively (p = 0.83). In the LTOT group, median survival was 38 days with best supportive care and 462 days with active treatment (p = 0.003). However, when adjusting on performance status and disease stage, LTOT was not significantly associated with a worse outcome. Hazard ratio (HR): 1.56 (95% confidence interval [CI]: 0.87 to 2.81) (p = 0.137). Administration of any treatment was associated with a better prognostic: HR: 0.35 (95% CI: 0.19 to 0.66). Both groups had a similar treatment safety profile. Conclusion Incidence of lung cancer in patients with LTOT was comparable to the general population. The proportion of LTOT patients who received active treatment was similar to controls, and overall survival did not differ from controls in a multivariate analysis. Although reaching a histological diagnosis may be challenging in LTOT patients, the efficacy and safety of the management strategies of lung cancer seem preserved. |
| first_indexed | 2024-04-11T02:09:38Z |
| format | Article |
| id | doaj.art-7839e1d5817644bfb3688a4a0cf7726a |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T02:09:38Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-7839e1d5817644bfb3688a4a0cf7726a2023-01-03T02:26:19ZengWileyThoracic Cancer1759-77061759-77142023-01-01141364310.1111/1759-7714.14692Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapyTimothée Lambert0Kinan El Husseini1Maeva Zysman2Boris Duchemann3André Gillibert4Luca Campedel5Edouard Dantoing6Camille Rolland‐Debord7Maxime Patout8Service de Pneumologie Centre Hospitalier Alpes Léman Contamine sur Arve FranceService de Pneumologie Oncologie thoracique Rouen FranceService de Pneumologie CHU Haut‐Lévèque Bordeaux FranceService d'oncologie Thoracique et médicale Hôpital Avicenne–APHP Bobigny FranceService de Biostatistiques CHU de Rouen Rouen FranceService d'Oncologie, CHU Gabriel Montpied Université Clermont Auvergne Clermont‐Ferrand FranceService de Pneumologie Oncologie thoracique Rouen FranceService de Pneumologie, CHU Gabriel Montpied Université Clermont Auvergne Clermont‐Ferrand FranceService de Pneumologie Oncologie thoracique Rouen FranceAbstract Background Here, we aimed to assess the specific features of lung cancer in patients with long‐term oxygen therapy (LTOT), and compare their outcomes with patients suffering from lung cancer without LTOT. Methods This retrospective, case‐controlled study included patients with LTOT and an incident diagnosis of lung cancer treated at Rouen University Hospital. Results Out of 2201 patients with LTOT, 31 were diagnosed with lung cancer. Among 24 patients with proven lung cancer, the most frequent histological type was squamous cell carcinoma (n = 12/24, 50%). Active treatment of any type was given in 19/31 (61%) and 41/62 (66%) of patients in the LTOT and control groups, respectively (p = 0.83). In the LTOT group, median survival was 38 days with best supportive care and 462 days with active treatment (p = 0.003). However, when adjusting on performance status and disease stage, LTOT was not significantly associated with a worse outcome. Hazard ratio (HR): 1.56 (95% confidence interval [CI]: 0.87 to 2.81) (p = 0.137). Administration of any treatment was associated with a better prognostic: HR: 0.35 (95% CI: 0.19 to 0.66). Both groups had a similar treatment safety profile. Conclusion Incidence of lung cancer in patients with LTOT was comparable to the general population. The proportion of LTOT patients who received active treatment was similar to controls, and overall survival did not differ from controls in a multivariate analysis. Although reaching a histological diagnosis may be challenging in LTOT patients, the efficacy and safety of the management strategies of lung cancer seem preserved.https://doi.org/10.1111/1759-7714.14692best supportive carelong‐term oxygen therapylung cancerstereotactic radiotherapy |
| spellingShingle | Timothée Lambert Kinan El Husseini Maeva Zysman Boris Duchemann André Gillibert Luca Campedel Edouard Dantoing Camille Rolland‐Debord Maxime Patout Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy Thoracic Cancer best supportive care long‐term oxygen therapy lung cancer stereotactic radiotherapy |
| title | Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy |
| title_full | Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy |
| title_fullStr | Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy |
| title_full_unstemmed | Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy |
| title_short | Incidence, management, and outcome of lung cancer in patients with long‐term oxygen therapy |
| title_sort | incidence management and outcome of lung cancer in patients with long term oxygen therapy |
| topic | best supportive care long‐term oxygen therapy lung cancer stereotactic radiotherapy |
| url | https://doi.org/10.1111/1759-7714.14692 |
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