Taking out TB – A role for lysosomal ubiquitin-derived peptides
Tuberculosis remains a significant global health concern. The hallmark of Mycobacterium tuberculosis pathogenicity is its ability to infect resting macrophages and establish an intracellular niche. Activated and autophagic macrophages control mycobacterial infections through bactericidal mechanisms...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00007/full |
| _version_ | 1818048557999980544 |
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| author | Georgiana ePurdy |
| author_facet | Georgiana ePurdy |
| author_sort | Georgiana ePurdy |
| collection | DOAJ |
| description | Tuberculosis remains a significant global health concern. The hallmark of Mycobacterium tuberculosis pathogenicity is its ability to infect resting macrophages and establish an intracellular niche. Activated and autophagic macrophages control mycobacterial infections through bactericidal mechanisms ranging from reactive oxygen and nitrogen intermediates to the delivery of the bacterium to the acidified, hydrolytically active lysosome. The mycobactericidal activity of the lysosome is due in part to the action of ubiquitin-derived peptides (Ub-peptides). In this review we discuss the trafficking events that result in delivery M. tuberculosis to the lysosome, the source and lysosomal generation of Ub-peptides and their role in macrophage control of M. tuberculosis infection. |
| first_indexed | 2024-12-10T10:23:35Z |
| format | Article |
| id | doaj.art-783a4602b5e94e3ca47f8868722030ab |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T10:23:35Z |
| publishDate | 2011-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-783a4602b5e94e3ca47f8868722030ab2022-12-22T01:52:48ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882011-01-01210.3389/fmicb.2011.000079141Taking out TB – A role for lysosomal ubiquitin-derived peptidesGeorgiana ePurdy0Oregon Health and Sciences UniversityTuberculosis remains a significant global health concern. The hallmark of Mycobacterium tuberculosis pathogenicity is its ability to infect resting macrophages and establish an intracellular niche. Activated and autophagic macrophages control mycobacterial infections through bactericidal mechanisms ranging from reactive oxygen and nitrogen intermediates to the delivery of the bacterium to the acidified, hydrolytically active lysosome. The mycobactericidal activity of the lysosome is due in part to the action of ubiquitin-derived peptides (Ub-peptides). In this review we discuss the trafficking events that result in delivery M. tuberculosis to the lysosome, the source and lysosomal generation of Ub-peptides and their role in macrophage control of M. tuberculosis infection.http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00007/fullAutophagyMycobacteriumTuberculosisUbiquitinLysosomeUb-peptides |
| spellingShingle | Georgiana ePurdy Taking out TB – A role for lysosomal ubiquitin-derived peptides Frontiers in Cellular and Infection Microbiology Autophagy Mycobacterium Tuberculosis Ubiquitin Lysosome Ub-peptides |
| title | Taking out TB – A role for lysosomal ubiquitin-derived peptides |
| title_full | Taking out TB – A role for lysosomal ubiquitin-derived peptides |
| title_fullStr | Taking out TB – A role for lysosomal ubiquitin-derived peptides |
| title_full_unstemmed | Taking out TB – A role for lysosomal ubiquitin-derived peptides |
| title_short | Taking out TB – A role for lysosomal ubiquitin-derived peptides |
| title_sort | taking out tb a role for lysosomal ubiquitin derived peptides |
| topic | Autophagy Mycobacterium Tuberculosis Ubiquitin Lysosome Ub-peptides |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00007/full |
| work_keys_str_mv | AT georgianaepurdy takingouttbaroleforlysosomalubiquitinderivedpeptides |