Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014
BackgroundThe potential relationship between Klotho and cognitive function is limited and controversial. This study aimed to quantify the association of Klotho and cognitive impairment in chronic kidney disease (CKD) patients with albuminuria.MethodsSerum Klotho was measured by enzyme-linked immunos...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1215977/full |
| _version_ | 1827893871047081984 |
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| author | Jialing Zhang Aihua Zhang Aihua Zhang |
| author_facet | Jialing Zhang Aihua Zhang Aihua Zhang |
| author_sort | Jialing Zhang |
| collection | DOAJ |
| description | BackgroundThe potential relationship between Klotho and cognitive function is limited and controversial. This study aimed to quantify the association of Klotho and cognitive impairment in chronic kidney disease (CKD) patients with albuminuria.MethodsSerum Klotho was measured by enzyme-linked immunosorbent assay. Patients with urine albumin to creatinine ratio (UACR) > 30mg/g from the National Health and Nutrition Survey (NHANES) 2011-2014 were divided into 4 groups according to the quartile of Klotho. Cognitive function was examined using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Digit Symbol Substitution Test (DSST), and Animal Fluency Test. The relationship between Klotho and cognitive function was analyzed by multivariable regression and subgroup analysis.ResultsAmong 368 CKD patients with albuminuria, we found that Klotho was negatively associated with creatinine, and positively associated with hemoglobin, and estimated glomerular filtration rate. No significant linear relationship was showed between Klotho (as a continuous variable) and cognitive function. When regarded Klotho as a category variable, patients in the quartile 3 group were at a better cognitive performance for CEARD-word learning subset and DSST, especially in the CKD patients with 30 mg/g < UACR <300 mg/g, but not in participants with UACR > 300 mg/g.ConclusionsThe increased Klotho was associated with an increased cognitive function in CKD patients with microalbuminuria. Further studies are needed to demonstrate whether Klotho may be a beneficial biomarker of cognitive health and neurodegeneration. |
| first_indexed | 2024-03-12T21:58:06Z |
| format | Article |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T21:58:06Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-783cc91ccf7545d080af29e9052cebfd2023-07-25T12:57:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.12159771215977Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014Jialing Zhang0Aihua Zhang1Aihua Zhang2Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBackgroundThe potential relationship between Klotho and cognitive function is limited and controversial. This study aimed to quantify the association of Klotho and cognitive impairment in chronic kidney disease (CKD) patients with albuminuria.MethodsSerum Klotho was measured by enzyme-linked immunosorbent assay. Patients with urine albumin to creatinine ratio (UACR) > 30mg/g from the National Health and Nutrition Survey (NHANES) 2011-2014 were divided into 4 groups according to the quartile of Klotho. Cognitive function was examined using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Digit Symbol Substitution Test (DSST), and Animal Fluency Test. The relationship between Klotho and cognitive function was analyzed by multivariable regression and subgroup analysis.ResultsAmong 368 CKD patients with albuminuria, we found that Klotho was negatively associated with creatinine, and positively associated with hemoglobin, and estimated glomerular filtration rate. No significant linear relationship was showed between Klotho (as a continuous variable) and cognitive function. When regarded Klotho as a category variable, patients in the quartile 3 group were at a better cognitive performance for CEARD-word learning subset and DSST, especially in the CKD patients with 30 mg/g < UACR <300 mg/g, but not in participants with UACR > 300 mg/g.ConclusionsThe increased Klotho was associated with an increased cognitive function in CKD patients with microalbuminuria. Further studies are needed to demonstrate whether Klotho may be a beneficial biomarker of cognitive health and neurodegeneration.https://www.frontiersin.org/articles/10.3389/fendo.2023.1215977/fullalbuminuriachronic kidney diseasecognition impairmentKlothoNHANES |
| spellingShingle | Jialing Zhang Aihua Zhang Aihua Zhang Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014 Frontiers in Endocrinology albuminuria chronic kidney disease cognition impairment Klotho NHANES |
| title | Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014 |
| title_full | Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014 |
| title_fullStr | Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014 |
| title_full_unstemmed | Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014 |
| title_short | Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014 |
| title_sort | relationships between serum klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in nhanes 2011 2014 |
| topic | albuminuria chronic kidney disease cognition impairment Klotho NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1215977/full |
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