Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches
<i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants, also known as Mexican tea, and locally known as Mkhinza, is a polymorphic annual and perennial herb, and it is widely used in folk medicine to treat a broad range of illnesses in Morocco. The aim of this study was to determine the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/4/482 |
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| author | Fahd Kandsi Amine Elbouzidi Fatima Zahra Lafdil Nada Meskali Ali Azghar Mohamed Addi Christophe Hano Adil Maleb Nadia Gseyra |
| author_facet | Fahd Kandsi Amine Elbouzidi Fatima Zahra Lafdil Nada Meskali Ali Azghar Mohamed Addi Christophe Hano Adil Maleb Nadia Gseyra |
| author_sort | Fahd Kandsi |
| collection | DOAJ |
| description | <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants, also known as Mexican tea, and locally known as Mkhinza, is a polymorphic annual and perennial herb, and it is widely used in folk medicine to treat a broad range of illnesses in Morocco. The aim of this study was to determine the phytochemical content and the antioxidant and the antibacterial properties of essential oils isolated from <i>D. ambrosioides</i> aerial components, growing in Eastern Morocco (Figuig). Hydrodistillation was used to separate <i>D. ambrosioides</i> essential oils, and the abundance of each phytocompound was determined by using Gas Chromatography coupled with Mass Spectrometry (GC–MS). In vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and inhibition of β-carotene/linoleic acid bleaching assays were used to determine <i>D. ambrosioides</i> essential oils’ antioxidant activity. The findings revealed relative antioxidative power and modest radical scavenging. The antibacterial activity of the essential oils was broad-spectrum, with <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Enterococcus faecalis</i> as the most susceptible strains tested. To elucidate the physicochemical nature, drug-likeness, and the antioxidant and antibacterial action of the identified phytocomponents, computational techniques, such as ADMET analysis, and molecular docking were used. |
| first_indexed | 2024-03-09T11:15:01Z |
| format | Article |
| id | doaj.art-783cfeb6e88d4b49b2bed1b54a8e075a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T11:15:01Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-783cfeb6e88d4b49b2bed1b54a8e075a2023-12-01T00:32:37ZengMDPI AGAntibiotics2079-63822022-04-0111448210.3390/antibiotics11040482Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational ApproachesFahd Kandsi0Amine Elbouzidi1Fatima Zahra Lafdil2Nada Meskali3Ali Azghar4Mohamed Addi5Christophe Hano6Adil Maleb7Nadia Gseyra8Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, B.P. 717, Oujda 60000, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda 60000, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, B.P. 717, Oujda 60000, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda 60000, MoroccoLaboratoire de Microbiologie, Centre Hospitalier Universitaire (CHU), Oujda 60000, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda 60000, MoroccoLaboratoire de Biologie des Ligneux et des Grandes Cultures, INRAE USC1328, University of Orleans, CEDEX 2, 45067 Orléans, FranceLaboratoire de Microbiologie, Centre Hospitalier Universitaire (CHU), Oujda 60000, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, B.P. 717, Oujda 60000, Morocco<i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants, also known as Mexican tea, and locally known as Mkhinza, is a polymorphic annual and perennial herb, and it is widely used in folk medicine to treat a broad range of illnesses in Morocco. The aim of this study was to determine the phytochemical content and the antioxidant and the antibacterial properties of essential oils isolated from <i>D. ambrosioides</i> aerial components, growing in Eastern Morocco (Figuig). Hydrodistillation was used to separate <i>D. ambrosioides</i> essential oils, and the abundance of each phytocompound was determined by using Gas Chromatography coupled with Mass Spectrometry (GC–MS). In vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and inhibition of β-carotene/linoleic acid bleaching assays were used to determine <i>D. ambrosioides</i> essential oils’ antioxidant activity. The findings revealed relative antioxidative power and modest radical scavenging. The antibacterial activity of the essential oils was broad-spectrum, with <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Enterococcus faecalis</i> as the most susceptible strains tested. To elucidate the physicochemical nature, drug-likeness, and the antioxidant and antibacterial action of the identified phytocomponents, computational techniques, such as ADMET analysis, and molecular docking were used.https://www.mdpi.com/2079-6382/11/4/482<i>Dysphania ambrosioides</i>antioxidant activityantimicrobial activityessential oilscomputational studymolecular docking |
| spellingShingle | Fahd Kandsi Amine Elbouzidi Fatima Zahra Lafdil Nada Meskali Ali Azghar Mohamed Addi Christophe Hano Adil Maleb Nadia Gseyra Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches Antibiotics <i>Dysphania ambrosioides</i> antioxidant activity antimicrobial activity essential oils computational study molecular docking |
| title | Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches |
| title_full | Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches |
| title_fullStr | Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches |
| title_full_unstemmed | Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches |
| title_short | Antibacterial and Antioxidant Activity of <i>Dysphania ambrosioides</i> (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches |
| title_sort | antibacterial and antioxidant activity of i dysphania ambrosioides i l mosyakin and clemants essential oils experimental and computational approaches |
| topic | <i>Dysphania ambrosioides</i> antioxidant activity antimicrobial activity essential oils computational study molecular docking |
| url | https://www.mdpi.com/2079-6382/11/4/482 |
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