Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo
The Parkinsons disease (PD) pathology is not limited by degenerationof the nigrostriatal dopaminergic system, but includesalso wide involvement of different regions of cerebral cortex. Theaim of this study was the identification of differences in the braincortical thickness in patients with early an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/228/61 |
| _version_ | 1818240579012657152 |
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| author | A. G. Trufanov I. V. Litvinenko M. M. Odinak L. V. Voronkov D. A. Khaimov A. Yu. Efimzev V. A. Fokin |
| author_facet | A. G. Trufanov I. V. Litvinenko M. M. Odinak L. V. Voronkov D. A. Khaimov A. Yu. Efimzev V. A. Fokin |
| author_sort | A. G. Trufanov |
| collection | DOAJ |
| description | The Parkinsons disease (PD) pathology is not limited by degenerationof the nigrostriatal dopaminergic system, but includesalso wide involvement of different regions of cerebral cortex. Theaim of this study was the identification of differences in the braincortical thickness in patients with early and advanced PD withthe use of MRI morphometry. Sixty seven PD patients withHoehn-Yahr 2 and 3 stages were examined. All patients underwentMRI with subsequent post-processing and receiving of corticalthickness parameters in different brain regions. Significantdifferences in the visual cortex, the cingulated and fusiform gyriand the frontopolar zone of a dominant hemisphere, and the Brodmanns areas 1, 2, 3 and 4 of a non-dominant hemispherewere obtained. These data allow revealing relationships betweennon-motor manifestations of PD and degeneration of certaincortical regions of the brain. |
| first_indexed | 2024-12-12T13:15:41Z |
| format | Article |
| id | doaj.art-783ea958c9bd4cea89f746a10979cc29 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T13:15:41Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-783ea958c9bd4cea89f746a10979cc292022-12-22T00:23:25ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0173374110.17816/psaic228123Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivoA. G. Trufanov0I. V. Litvinenko1M. M. Odinak2L. V. Voronkov3D. A. Khaimov4A. Yu. Efimzev5V. A. Fokin6Military Medical Academy named after S.M. Kirov (St.-Petersburg)Military Medical Academy named after S.M. Kirov (St.-Petersburg)Military Medical Academy named after S.M. Kirov (St.-Petersburg)Military Medical Academy named after S.M. Kirov (St.-Petersburg)Military Medical Academy named after S.M. Kirov (St.-Petersburg)Military Medical Academy named after S.M. Kirov (St.-Petersburg)Military Medical Academy named after S.M. Kirov (St.-Petersburg)The Parkinsons disease (PD) pathology is not limited by degenerationof the nigrostriatal dopaminergic system, but includesalso wide involvement of different regions of cerebral cortex. Theaim of this study was the identification of differences in the braincortical thickness in patients with early and advanced PD withthe use of MRI morphometry. Sixty seven PD patients withHoehn-Yahr 2 and 3 stages were examined. All patients underwentMRI with subsequent post-processing and receiving of corticalthickness parameters in different brain regions. Significantdifferences in the visual cortex, the cingulated and fusiform gyriand the frontopolar zone of a dominant hemisphere, and the Brodmanns areas 1, 2, 3 and 4 of a non-dominant hemispherewere obtained. These data allow revealing relationships betweennon-motor manifestations of PD and degeneration of certaincortical regions of the brain.https://annaly-nevrologii.com/journal/pathID/article/viewFile/228/61parkinson diseasecortical atrophymri morphometry |
| spellingShingle | A. G. Trufanov I. V. Litvinenko M. M. Odinak L. V. Voronkov D. A. Khaimov A. Yu. Efimzev V. A. Fokin Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo Анналы клинической и экспериментальной неврологии parkinson disease cortical atrophy mri morphometry |
| title | Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo |
| title_full | Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo |
| title_fullStr | Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo |
| title_full_unstemmed | Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo |
| title_short | Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo |
| title_sort | cortical cerebral atrophy in patients with parkinson s disease new trends in the diagnostics in vivo |
| topic | parkinson disease cortical atrophy mri morphometry |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/228/61 |
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