Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI
The human visual system comprises elongated fiber pathways that represent a serious challenge for diffusion tensor imaging (DTI) and fiber tractography: while tracking of frontal fiber bundles may be compromised by the nearby presence of air-filled cavities, nerves, and eye muscles, the anatomic cou...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2010-04-01
|
| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00015/full |
| _version_ | 1818906920204894208 |
|---|---|
| author | Sabine Hofer Alexander Karaus Jens Frahm |
| author_facet | Sabine Hofer Alexander Karaus Jens Frahm |
| author_sort | Sabine Hofer |
| collection | DOAJ |
| description | The human visual system comprises elongated fiber pathways that represent a serious challenge for diffusion tensor imaging (DTI) and fiber tractography: while tracking of frontal fiber bundles may be compromised by the nearby presence of air-filled cavities, nerves, and eye muscles, the anatomic courses of the three main fiber bundles of the optic radiation are subject to pronounced inter-subject variability. Here, tractography of the entire visual pathway was achieved in 6 healthy subjects at high spatial accuracy, that is at 1.8 mm isotropic spatial resolution, without susceptibility-induced distortions, and in direct correspondence to anatomic MRI structures. Using a newly developed diffusion-weighted single-shot STEAM MRI sequence, we were able to track the thin optic nerve including the nasal optic nerve fibers, which cross the optic chiasm, and to dissect the optic radiation into the anterior ventral bundle (Meyer’s loop), the central bundle, and the dorsal bundle. Apart from scientific applications these results in single subjects promise advances in the planning of neurosurgical procedures to avoid unnecessary damage to the visual fiber system. |
| first_indexed | 2024-12-19T21:46:53Z |
| format | Article |
| id | doaj.art-78407d7f087f4cbe821b92dc0fff98c6 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-19T21:46:53Z |
| publishDate | 2010-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-78407d7f087f4cbe821b92dc0fff98c62022-12-21T20:04:31ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292010-04-01410.3389/fnana.2010.000151037Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRISabine Hofer0Alexander Karaus1Jens Frahm2Max-Planck-Institut für biophysikalische ChemieMax-Planck-Institut für biophysikalische ChemieMax-Planck-Institut für biophysikalische ChemieThe human visual system comprises elongated fiber pathways that represent a serious challenge for diffusion tensor imaging (DTI) and fiber tractography: while tracking of frontal fiber bundles may be compromised by the nearby presence of air-filled cavities, nerves, and eye muscles, the anatomic courses of the three main fiber bundles of the optic radiation are subject to pronounced inter-subject variability. Here, tractography of the entire visual pathway was achieved in 6 healthy subjects at high spatial accuracy, that is at 1.8 mm isotropic spatial resolution, without susceptibility-induced distortions, and in direct correspondence to anatomic MRI structures. Using a newly developed diffusion-weighted single-shot STEAM MRI sequence, we were able to track the thin optic nerve including the nasal optic nerve fibers, which cross the optic chiasm, and to dissect the optic radiation into the anterior ventral bundle (Meyer’s loop), the central bundle, and the dorsal bundle. Apart from scientific applications these results in single subjects promise advances in the planning of neurosurgical procedures to avoid unnecessary damage to the visual fiber system.http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00015/fullOptic ChiasmDTIhuman brainfiber tractographyMeyer |
| spellingShingle | Sabine Hofer Alexander Karaus Jens Frahm Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI Frontiers in Neuroanatomy Optic Chiasm DTI human brain fiber tractography Meyer |
| title | Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI |
| title_full | Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI |
| title_fullStr | Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI |
| title_full_unstemmed | Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI |
| title_short | Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI |
| title_sort | reconstruction and dissection of the entire human visual pathway using diffusion tensor mri |
| topic | Optic Chiasm DTI human brain fiber tractography Meyer |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00015/full |
| work_keys_str_mv | AT sabinehofer reconstructionanddissectionoftheentirehumanvisualpathwayusingdiffusiontensormri AT alexanderkaraus reconstructionanddissectionoftheentirehumanvisualpathwayusingdiffusiontensormri AT jensfrahm reconstructionanddissectionoftheentirehumanvisualpathwayusingdiffusiontensormri |