Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
Numerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, <i>SLC6A2 (</i>rs1805065) and <i>SYNE1</i> (rs2635438) in a group of 890 a...
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/6/919 |
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| author | Jakub P. Fichna Kinga Humińska-Lisowska Krzysztof Safranow Jakub G. Adamczyk Paweł Cięszczyk Cezary Żekanowski Mariusz Berdyński |
| author_facet | Jakub P. Fichna Kinga Humińska-Lisowska Krzysztof Safranow Jakub G. Adamczyk Paweł Cięszczyk Cezary Żekanowski Mariusz Berdyński |
| author_sort | Jakub P. Fichna |
| collection | DOAJ |
| description | Numerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, <i>SLC6A2 (</i>rs1805065) and <i>SYNE1</i> (rs2635438) in a group of 890 athletes (320 endurance, 265 power, and 305 combat athletes) vs. 1009 sedentary controls. Genotyping of selected SNPs was performed using TaqMan SNP genotyping assays. <i>SLC6A2</i> codes for norepinephrine transporter, a protein involved in modulating mood, arousal, memory, learning, and pain perception, while <i>SYNE1</i> encodes protein important for the maintenance of the cerebellum—the part of the brain that coordinates complex body movements. Both SNPs (rs2635438 and rs1805065) showed no statistically significant differences between the frequencies of variants in the athletes and the sedentary controls (athletes vs. control group) or in the athlete subgroups (martial vs. control, endurance vs. control, and power vs. control). The rs1805065 T variant of <i>SLC6A2</i> was found to be overrepresented in male high-elite martial sports athletes when compared to sedentary controls (OR = 6.56, 95%CI = 1.82–23.59, <i>p</i> = 0.010). This supports the hypothesis that genetic variants potentially affecting brain functioning can influence elite athletic performance and indicate the need for further genetic association studies, as well as functional analyses. |
| first_indexed | 2024-03-10T10:23:33Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T10:23:33Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-78411f87824d4f58b1ce4f9a2fe1ae402023-11-22T00:13:43ZengMDPI AGGenes2073-44252021-06-0112691910.3390/genes12060919Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish PopulationJakub P. Fichna0Kinga Humińska-Lisowska1Krzysztof Safranow2Jakub G. Adamczyk3Paweł Cięszczyk4Cezary Żekanowski5Mariusz Berdyński6Department of Neurodegenerative Disorders, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-204 Szczecin, PolandDepartment of Theory of Sport, Józef Piłsudski University of Physical Education, 00-968 Warsaw, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandDepartment of Neurodegenerative Disorders, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandDepartment of Neurodegenerative Disorders, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandNumerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, <i>SLC6A2 (</i>rs1805065) and <i>SYNE1</i> (rs2635438) in a group of 890 athletes (320 endurance, 265 power, and 305 combat athletes) vs. 1009 sedentary controls. Genotyping of selected SNPs was performed using TaqMan SNP genotyping assays. <i>SLC6A2</i> codes for norepinephrine transporter, a protein involved in modulating mood, arousal, memory, learning, and pain perception, while <i>SYNE1</i> encodes protein important for the maintenance of the cerebellum—the part of the brain that coordinates complex body movements. Both SNPs (rs2635438 and rs1805065) showed no statistically significant differences between the frequencies of variants in the athletes and the sedentary controls (athletes vs. control group) or in the athlete subgroups (martial vs. control, endurance vs. control, and power vs. control). The rs1805065 T variant of <i>SLC6A2</i> was found to be overrepresented in male high-elite martial sports athletes when compared to sedentary controls (OR = 6.56, 95%CI = 1.82–23.59, <i>p</i> = 0.010). This supports the hypothesis that genetic variants potentially affecting brain functioning can influence elite athletic performance and indicate the need for further genetic association studies, as well as functional analyses.https://www.mdpi.com/2073-4425/12/6/919athletic performancesingle nucleotide polymorphismendurance sportspower sportscombat sports |
| spellingShingle | Jakub P. Fichna Kinga Humińska-Lisowska Krzysztof Safranow Jakub G. Adamczyk Paweł Cięszczyk Cezary Żekanowski Mariusz Berdyński Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population Genes athletic performance single nucleotide polymorphism endurance sports power sports combat sports |
| title | Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population |
| title_full | Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population |
| title_fullStr | Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population |
| title_full_unstemmed | Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population |
| title_short | Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population |
| title_sort | rare variant in the slc6a2 encoding a norepinephrine transporter is associated with elite athletic performance in the polish population |
| topic | athletic performance single nucleotide polymorphism endurance sports power sports combat sports |
| url | https://www.mdpi.com/2073-4425/12/6/919 |
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