Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies
The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types (endothelial cells, smooth muscle cells, macrophages, and others), compone...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2022-09-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-069.pdf |
| _version_ | 1811216167222640640 |
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| author | Verdiana Ravarotto Giovanni Bertoldi Lucia Federica Stefanelli Federico Nalesso Lorenzo A. Calò |
| author_facet | Verdiana Ravarotto Giovanni Bertoldi Lucia Federica Stefanelli Federico Nalesso Lorenzo A. Calò |
| author_sort | Verdiana Ravarotto |
| collection | DOAJ |
| description | The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types (endothelial cells, smooth muscle cells, macrophages, and others), components of the vasculature, glomeruli, and heart that are susceptible to oxidative damage and structural alterations. A vicious cycle occurs whereby harmful factors such as reactive oxygen species and inflammation damage of vascular structures that themselves become sources of additional dangerous/toxic components released into the local environment. The evidence of this vicious cycle in chronic kidney disease should therefore lead to add other factors to both traditional and nontraditional risk factors. This review will examine the processes occurring during progressive kidney dysfunction with regard to vascular injury, renal remodeling, cardiac hypertrophy, and the transversal role of oxidative stress in the development of these complications. |
| first_indexed | 2024-04-12T06:34:39Z |
| format | Article |
| id | doaj.art-7841706e407849eda27ef3ee5181afc1 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-12T06:34:39Z |
| publishDate | 2022-09-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-7841706e407849eda27ef3ee5181afc12022-12-22T03:43:55ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402022-09-0141553354410.23876/j.krcp.22.0696174Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategiesVerdiana Ravarotto0Giovanni Bertoldi1Lucia Federica Stefanelli2Federico Nalesso3Lorenzo A. Calò4 Division of Nephrology, Dialysis and Transplantation, Department of Medicine (DIMED), School of Medicine, University of Padova, Padova, Division of Nephrology, Dialysis and Transplantation, Department of Medicine (DIMED), School of Medicine, University of Padova, Padova, Division of Nephrology, Dialysis and Transplantation, Department of Medicine (DIMED), School of Medicine, University of Padova, Padova, Division of Nephrology, Dialysis and Transplantation, Department of Medicine (DIMED), School of Medicine, University of Padova, Padova, Division of Nephrology, Dialysis and Transplantation, Department of Medicine (DIMED), School of Medicine, University of Padova, Padova, The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types (endothelial cells, smooth muscle cells, macrophages, and others), components of the vasculature, glomeruli, and heart that are susceptible to oxidative damage and structural alterations. A vicious cycle occurs whereby harmful factors such as reactive oxygen species and inflammation damage of vascular structures that themselves become sources of additional dangerous/toxic components released into the local environment. The evidence of this vicious cycle in chronic kidney disease should therefore lead to add other factors to both traditional and nontraditional risk factors. This review will examine the processes occurring during progressive kidney dysfunction with regard to vascular injury, renal remodeling, cardiac hypertrophy, and the transversal role of oxidative stress in the development of these complications.http://www.krcp-ksn.org/upload/pdf/j-krcp-22-069.pdfantioxidant response elementsinflammationkidneyreactive oxygen speciesredox balance |
| spellingShingle | Verdiana Ravarotto Giovanni Bertoldi Lucia Federica Stefanelli Federico Nalesso Lorenzo A. Calò Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies Kidney Research and Clinical Practice antioxidant response elements inflammation kidney reactive oxygen species redox balance |
| title | Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies |
| title_full | Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies |
| title_fullStr | Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies |
| title_full_unstemmed | Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies |
| title_short | Pathomechanism of oxidative stress in cardiovascular-renal remodeling and therapeutic strategies |
| title_sort | pathomechanism of oxidative stress in cardiovascular renal remodeling and therapeutic strategies |
| topic | antioxidant response elements inflammation kidney reactive oxygen species redox balance |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-069.pdf |
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