Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences
Perinatal hypoxic ischemic encephalopathy (HIE) among important causes of neurological morbidity and mortality in full-term neonates. Identifying ischemic injury clinically usually is difficult in the immediate postnatal period, nonspecific clinical features are present and consid-erations regarding...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Deccan College of Medical Sciences
2021-07-01
|
| Series: | Journal of Medical and Allied Sciences |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=74980 |
| _version_ | 1797774488911216640 |
|---|---|
| author | Imtiyaz Ahmad Khan Nadia Khurshid Irshad Paul Feroze Shaheen Mushtaq Ahmad Bhat |
| author_facet | Imtiyaz Ahmad Khan Nadia Khurshid Irshad Paul Feroze Shaheen Mushtaq Ahmad Bhat |
| author_sort | Imtiyaz Ahmad Khan |
| collection | DOAJ |
| description | Perinatal hypoxic ischemic encephalopathy (HIE) among important causes of neurological morbidity and mortality in full-term neonates. Identifying ischemic injury clinically usually is difficult in the immediate postnatal period, nonspecific clinical features are present and consid-erations regarding initiation of active life preserving therapies are needed. MR imaging is the most sensitive and specific imaging tech-nique available for the assessment of perinatal birth asphyxia related brain injury in term-born neonates. This study investigates the utility of MR spectroscopy peak ratios, ADC values along with conventional MRI. To compare the association of encephalopathy following hypoxia in term neonates with proton MRS ratios and ADC values. Conventional MRI (T1 and T2) along with DWI followed by MR Spectroscopy was done in 25 term neonates with clinical and neurological features of en-cephalopathy following perinatal asphyxia. MRS peak ratios, DWI with ADC values and conventional MRI findings were compared with each grade of HIE. Among 25 patients suspected cases of hypoxic enceph-alopathy, 15 patients had early positive conventional MR findings, 16 patients had late positive conventional MR findings, 19 patients had positive DWI, and 22 patients had positive MRS with high lac-tate/choline and lactate/NAA ratio. Higher association was found be-tween spectroscopy findings and hypoxic ischemic injury compared to MR imaging and ADC. The combination of MRS, DWI with ADC values and conventional MRI may assist in localizing and predicting the severi-ty of ischemic injury in HIE patients. [J Med Allied Sci. 2021; 11(2):178-182] |
| first_indexed | 2024-03-12T22:20:49Z |
| format | Article |
| id | doaj.art-7843ce49f86243f495c62f7a42d8d359 |
| institution | Directory Open Access Journal |
| issn | 2231-1696 2231-170X |
| language | English |
| last_indexed | 2024-03-12T22:20:49Z |
| publishDate | 2021-07-01 |
| publisher | Deccan College of Medical Sciences |
| record_format | Article |
| series | Journal of Medical and Allied Sciences |
| spelling | doaj.art-7843ce49f86243f495c62f7a42d8d3592023-07-23T07:47:12ZengDeccan College of Medical SciencesJournal of Medical and Allied Sciences2231-16962231-170X2021-07-0111217818210.5455/jmas.7498074980Evaluation of perinatal hypoxic encephalopathy with advanced MR sequencesImtiyaz Ahmad Khan0Nadia Khurshid1Irshad Paul2Feroze Shaheen3Mushtaq Ahmad Bhat4Department of Pediatrics, Government Medical College, Srinagar-190010, Jammu and Kashmir, IndiaGovernment Medical College, Baramulla-193103, Jammu And Kashmir, IndiaSher-i-Kashmir Institute of Medical Sciences, Srinagar-190011, Jammu and Kashmir, IndiaSher-i-Kashmir Institute of Medical Sciences, Srinagar-190011, Jammu and Kashmir, IndiaSher-i-Kashmir Institute of Medical Sciences, Srinagar-190011, Jammu and Kashmir, IndiaPerinatal hypoxic ischemic encephalopathy (HIE) among important causes of neurological morbidity and mortality in full-term neonates. Identifying ischemic injury clinically usually is difficult in the immediate postnatal period, nonspecific clinical features are present and consid-erations regarding initiation of active life preserving therapies are needed. MR imaging is the most sensitive and specific imaging tech-nique available for the assessment of perinatal birth asphyxia related brain injury in term-born neonates. This study investigates the utility of MR spectroscopy peak ratios, ADC values along with conventional MRI. To compare the association of encephalopathy following hypoxia in term neonates with proton MRS ratios and ADC values. Conventional MRI (T1 and T2) along with DWI followed by MR Spectroscopy was done in 25 term neonates with clinical and neurological features of en-cephalopathy following perinatal asphyxia. MRS peak ratios, DWI with ADC values and conventional MRI findings were compared with each grade of HIE. Among 25 patients suspected cases of hypoxic enceph-alopathy, 15 patients had early positive conventional MR findings, 16 patients had late positive conventional MR findings, 19 patients had positive DWI, and 22 patients had positive MRS with high lac-tate/choline and lactate/NAA ratio. Higher association was found be-tween spectroscopy findings and hypoxic ischemic injury compared to MR imaging and ADC. The combination of MRS, DWI with ADC values and conventional MRI may assist in localizing and predicting the severi-ty of ischemic injury in HIE patients. [J Med Allied Sci. 2021; 11(2):178-182]http://www.ejmanager.com/fulltextpdf.php?mno=74980perinatal hypoxiatermpre-termencephalopathyhie |
| spellingShingle | Imtiyaz Ahmad Khan Nadia Khurshid Irshad Paul Feroze Shaheen Mushtaq Ahmad Bhat Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences Journal of Medical and Allied Sciences perinatal hypoxia term pre-term encephalopathy hie |
| title | Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences |
| title_full | Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences |
| title_fullStr | Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences |
| title_full_unstemmed | Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences |
| title_short | Evaluation of perinatal hypoxic encephalopathy with advanced MR sequences |
| title_sort | evaluation of perinatal hypoxic encephalopathy with advanced mr sequences |
| topic | perinatal hypoxia term pre-term encephalopathy hie |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=74980 |
| work_keys_str_mv | AT imtiyazahmadkhan evaluationofperinatalhypoxicencephalopathywithadvancedmrsequences AT nadiakhurshid evaluationofperinatalhypoxicencephalopathywithadvancedmrsequences AT irshadpaul evaluationofperinatalhypoxicencephalopathywithadvancedmrsequences AT ferozeshaheen evaluationofperinatalhypoxicencephalopathywithadvancedmrsequences AT mushtaqahmadbhat evaluationofperinatalhypoxicencephalopathywithadvancedmrsequences |