Language Dominance in Patients With Malformations of Cortical Development and Epilepsy
Background: Language function may be reorganized in patients with malformations of cortical development (MCD). This prospective cohort study aimed in assessing language dominance in a large group of patients with MCD and epilepsy using functional MRI (fMRI).Methods: Sixty-eight patients (40 women) a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01209/full |
| _version_ | 1818570427620917248 |
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| author | Giorgi Kuchukhidze Giorgi Kuchukhidze Christian Siedentopf Iris Unterberger Florian Koppelstaetter Florian Koppelstaetter Martin Kronbichler Martin Kronbichler Martin Kronbichler Laura Zamarian Edda Haberlandt Edda Haberlandt Anja Ischebeck Margarete Delazer Stephan Felber Eugen Trinka Eugen Trinka Eugen Trinka |
| author_facet | Giorgi Kuchukhidze Giorgi Kuchukhidze Christian Siedentopf Iris Unterberger Florian Koppelstaetter Florian Koppelstaetter Martin Kronbichler Martin Kronbichler Martin Kronbichler Laura Zamarian Edda Haberlandt Edda Haberlandt Anja Ischebeck Margarete Delazer Stephan Felber Eugen Trinka Eugen Trinka Eugen Trinka |
| author_sort | Giorgi Kuchukhidze |
| collection | DOAJ |
| description | Background: Language function may be reorganized in patients with malformations of cortical development (MCD). This prospective cohort study aimed in assessing language dominance in a large group of patients with MCD and epilepsy using functional MRI (fMRI).Methods: Sixty-eight patients (40 women) aged 10–73 years (median, 28.0; interquartile range, 19) with MCD and epilepsy underwent 1.5 T MRI and fMRI (word generation task). Single-subject image analysis was performed with statistical parametric mapping (SPM12). Language lateralization indices (LIs) were defined for statistically significantly activated voxels in Broca's and Wernicke's areas using the formula: LI = (VL – VR)/(VL + VR) × 100, where VL and VR were sets of activated voxels on the left and on the right, respectively. Language laterality was considered typical if LI was between +20 and +100 or atypical if LI was between +19 and −100.Results: fMRI signal was elicited in 55 of 68 (81%) patients. In 18 of 55 (33%) patients, language dominance was typical, and in 37 of 55 (67%) patients, atypical (in 68%, right hemispheric; in 32%, bilateral). Language dominance was not influenced by handedness, electroclinical, and imaging features.Conclusions: In this prospective study on a large group of patients with MCD and epilepsy, about two-thirds had atypical language dominance. These results may contribute to assessing risks of postsurgical language deficits and could assist in planning of “cortical mapping” with intracranial electrodes in patients who undergo presurgical assessment. |
| first_indexed | 2024-12-14T13:41:09Z |
| format | Article |
| id | doaj.art-784449df1d084e908c4f6aea0abf7ce3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T13:41:09Z |
| publishDate | 2019-11-01 |
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| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-784449df1d084e908c4f6aea0abf7ce32022-12-21T22:59:26ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-11-011010.3389/fneur.2019.01209473631Language Dominance in Patients With Malformations of Cortical Development and EpilepsyGiorgi Kuchukhidze0Giorgi Kuchukhidze1Christian Siedentopf2Iris Unterberger3Florian Koppelstaetter4Florian Koppelstaetter5Martin Kronbichler6Martin Kronbichler7Martin Kronbichler8Laura Zamarian9Edda Haberlandt10Edda Haberlandt11Anja Ischebeck12Margarete Delazer13Stephan Felber14Eugen Trinka15Eugen Trinka16Eugen Trinka17Department of Neurology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurology, Christian Doppler Klinik, Paracelsus Medical University of Salzburg, Salzburg, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Radiology, Sanatorium Kettenbrücke, Innsbruck, AustriaNeuroscience Institute, Christian Doppler Klinik, Paracelsus Medical University of Salzburg, Salzburg, AustriaDepartment of Psychology, University of Salzburg, Salzburg, AustriaCentre for Cognitive Neuroscience, University of Salzburg, Salzburg, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics I, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics, City Hospital, Dornbirn, Austria0Institute of Psychology, University of Graz, Graz, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria1Department of Diagnostic and Interventional Radiology and Neuroradiology, Gemeinschaftsklinikum Mittelrhein, Koblenz, GermanyDepartment of Neurology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurology, Christian Doppler Klinik, Paracelsus Medical University of Salzburg, Salzburg, AustriaCentre for Cognitive Neuroscience, University of Salzburg, Salzburg, AustriaBackground: Language function may be reorganized in patients with malformations of cortical development (MCD). This prospective cohort study aimed in assessing language dominance in a large group of patients with MCD and epilepsy using functional MRI (fMRI).Methods: Sixty-eight patients (40 women) aged 10–73 years (median, 28.0; interquartile range, 19) with MCD and epilepsy underwent 1.5 T MRI and fMRI (word generation task). Single-subject image analysis was performed with statistical parametric mapping (SPM12). Language lateralization indices (LIs) were defined for statistically significantly activated voxels in Broca's and Wernicke's areas using the formula: LI = (VL – VR)/(VL + VR) × 100, where VL and VR were sets of activated voxels on the left and on the right, respectively. Language laterality was considered typical if LI was between +20 and +100 or atypical if LI was between +19 and −100.Results: fMRI signal was elicited in 55 of 68 (81%) patients. In 18 of 55 (33%) patients, language dominance was typical, and in 37 of 55 (67%) patients, atypical (in 68%, right hemispheric; in 32%, bilateral). Language dominance was not influenced by handedness, electroclinical, and imaging features.Conclusions: In this prospective study on a large group of patients with MCD and epilepsy, about two-thirds had atypical language dominance. These results may contribute to assessing risks of postsurgical language deficits and could assist in planning of “cortical mapping” with intracranial electrodes in patients who undergo presurgical assessment.https://www.frontiersin.org/article/10.3389/fneur.2019.01209/fullmalformations of cortical developmentepilepsylanguagefunctional MRIepilepsy surgery |
| spellingShingle | Giorgi Kuchukhidze Giorgi Kuchukhidze Christian Siedentopf Iris Unterberger Florian Koppelstaetter Florian Koppelstaetter Martin Kronbichler Martin Kronbichler Martin Kronbichler Laura Zamarian Edda Haberlandt Edda Haberlandt Anja Ischebeck Margarete Delazer Stephan Felber Eugen Trinka Eugen Trinka Eugen Trinka Language Dominance in Patients With Malformations of Cortical Development and Epilepsy Frontiers in Neurology malformations of cortical development epilepsy language functional MRI epilepsy surgery |
| title | Language Dominance in Patients With Malformations of Cortical Development and Epilepsy |
| title_full | Language Dominance in Patients With Malformations of Cortical Development and Epilepsy |
| title_fullStr | Language Dominance in Patients With Malformations of Cortical Development and Epilepsy |
| title_full_unstemmed | Language Dominance in Patients With Malformations of Cortical Development and Epilepsy |
| title_short | Language Dominance in Patients With Malformations of Cortical Development and Epilepsy |
| title_sort | language dominance in patients with malformations of cortical development and epilepsy |
| topic | malformations of cortical development epilepsy language functional MRI epilepsy surgery |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01209/full |
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