Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy
Perception of spatial orientation is thought to rely on the brain’s integration of visual, vestibular, proprioceptive, and somatosensory signals, as well as internal beliefs. When one of these signals breaks down, such as the vestibular signal in bilateral vestibulopathy, patients start compensating...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00377/full |
| _version_ | 1828198942363353088 |
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| author | W. Pieter Medendorp Bart B. G. T. Alberts Wim I. M. Verhagen Mathieu Koppen Luc P. J. Selen |
| author_facet | W. Pieter Medendorp Bart B. G. T. Alberts Wim I. M. Verhagen Mathieu Koppen Luc P. J. Selen |
| author_sort | W. Pieter Medendorp |
| collection | DOAJ |
| description | Perception of spatial orientation is thought to rely on the brain’s integration of visual, vestibular, proprioceptive, and somatosensory signals, as well as internal beliefs. When one of these signals breaks down, such as the vestibular signal in bilateral vestibulopathy, patients start compensating by relying more on the remaining cues. How these signals are reweighted in this integration process is difficult to establish, since they cannot be measured in isolation during natural tasks, are inherently noisy, and can be ambiguous or in conflict. Here, we review our recent work, combining experimental psychophysics with a reverse engineering approach, based on Bayesian inference principles, to quantify sensory noise levels and optimal (re)weighting at the individual subject level, in both patients with bilateral vestibular deficits and healthy controls. We show that these patients reweight the remaining sensory information, relying more on visual and other nonvestibular information than healthy controls in the perception of spatial orientation. This quantification approach could improve diagnostics and prognostics of multisensory integration deficits in vestibular patients, and contribute to an evaluation of rehabilitation therapies directed toward specific training programs. |
| first_indexed | 2024-04-12T10:46:44Z |
| format | Article |
| id | doaj.art-78457e30ad9a4cfda7d491a6a2f6a5b3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T10:46:44Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-78457e30ad9a4cfda7d491a6a2f6a5b32022-12-22T03:36:25ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-05-01910.3389/fneur.2018.00377356485Psychophysical Evaluation of Sensory Reweighting in Bilateral VestibulopathyW. Pieter Medendorp0Bart B. G. T. Alberts1Wim I. M. Verhagen2Mathieu Koppen3Luc P. J. Selen4Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, NetherlandsRadboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, NetherlandsDepartment of Neurology, Canisius Wilhelmina Hospital, Nijmegen, NetherlandsRadboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, NetherlandsRadboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, NetherlandsPerception of spatial orientation is thought to rely on the brain’s integration of visual, vestibular, proprioceptive, and somatosensory signals, as well as internal beliefs. When one of these signals breaks down, such as the vestibular signal in bilateral vestibulopathy, patients start compensating by relying more on the remaining cues. How these signals are reweighted in this integration process is difficult to establish, since they cannot be measured in isolation during natural tasks, are inherently noisy, and can be ambiguous or in conflict. Here, we review our recent work, combining experimental psychophysics with a reverse engineering approach, based on Bayesian inference principles, to quantify sensory noise levels and optimal (re)weighting at the individual subject level, in both patients with bilateral vestibular deficits and healthy controls. We show that these patients reweight the remaining sensory information, relying more on visual and other nonvestibular information than healthy controls in the perception of spatial orientation. This quantification approach could improve diagnostics and prognostics of multisensory integration deficits in vestibular patients, and contribute to an evaluation of rehabilitation therapies directed toward specific training programs.https://www.frontiersin.org/article/10.3389/fneur.2018.00377/fullspatial orientationvertical perceptionmultisensory integrationsensory reweightingrod-and-framebilateral vestibular areflexia |
| spellingShingle | W. Pieter Medendorp Bart B. G. T. Alberts Wim I. M. Verhagen Mathieu Koppen Luc P. J. Selen Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy Frontiers in Neurology spatial orientation vertical perception multisensory integration sensory reweighting rod-and-frame bilateral vestibular areflexia |
| title | Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy |
| title_full | Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy |
| title_fullStr | Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy |
| title_full_unstemmed | Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy |
| title_short | Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy |
| title_sort | psychophysical evaluation of sensory reweighting in bilateral vestibulopathy |
| topic | spatial orientation vertical perception multisensory integration sensory reweighting rod-and-frame bilateral vestibular areflexia |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00377/full |
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