C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings.

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings.

OBJECTIVE:The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. DESIGN:Nested case-control study (n = 332) within ACTG PEARLS trial of three ART regimens among 1571 HIV-infected, tre...

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Main Authors: Mark W Tenforde, Nikhil Gupte, David W Dowdy, David M Asmuth, Ashwin Balagopal, Richard B Pollard, Patcharaphan Sugandhavesa, Javier R Lama, Sandy Pillay, Sandra W Cardoso, Jyoti Pawar, Breno Santos, Cynthia Riviere, Noluthando Mwelase, Cecilia Kanyama, Johnstone Kumwenda, James G Hakim, Nagalingeswaran Kumarasamy, Robert Bollinger, Richard D Semba, Thomas B Campbell, Amita Gupta, ACTG PEARLS and NWCS 319 Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4342263?pdf=render

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