Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime

Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime

11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one oxime (<b>IQ-1</b>) and tryptanthrin-6-oxime are potent c-Jun N-terminal kinase 3 (JNK-3) inhibitors demonstrating neuroprotective, anti-inflammatory and anti-arthritic activity. However, the stereochemical configur...

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Bibliographic Details
Main Authors: Vladislava V. Matveevskaya, Dmitry I. Pavlov, Anastasia R. Kovrizhina, Taisiya S. Sukhikh, Evgeniy H. Sadykov, Pavel V. Dorovatovskii, Vladimir A. Lazarenko, Andrei I. Khlebnikov, Andrei S. Potapov
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
kinase inhibitor
oxime
crystal structure
nuclear magnetic resonance
rotation barrier
Online Access:https://www.mdpi.com/1999-4923/15/7/1802

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