The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah
Background: Parathyroid hormone (PTH) has been reported to have a positive correlation with insulin resistance and the development of the metabolic syndrome. This study aims to evaluate if there is an association between obesity and serum PTH levels. Methods: This case-control study was conducted at...
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| Format: | Article |
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Knowledge E
2021-12-01
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| Series: | Dubai Diabetes and Endocrinology Journal |
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| Online Access: | https://www.karger.com/Article/FullText/520660 |
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| author | Mohammed Khazaal Jumaahm Ali Hussain Ali Alhamza Abbas Ali Mansour |
| author_facet | Mohammed Khazaal Jumaahm Ali Hussain Ali Alhamza Abbas Ali Mansour |
| author_sort | Mohammed Khazaal Jumaahm |
| collection | DOAJ |
| description | Background: Parathyroid hormone (PTH) has been reported to have a positive correlation with insulin resistance and the development of the metabolic syndrome. This study aims to evaluate if there is an association between obesity and serum PTH levels. Methods: This case-control study was conducted at the Faiha Specialized Diabetes Endocrine and Metabolism Center in Basrah (Southern Iraq) from September 2018 to July 2019. A total of 230 patients were recruited for this study (103 male and 127 female), divided into 2 groups according to the BMI: <30 kg/m2 were considered as the control group (83 persons) and ≥30 kg/m2 were considered as obese persons (147 persons). The study groups were also subdivided into 3 groups according to the serum level of PTH: <40 pg/mL, 40–65 pg/mL, and >65 pg/mL. Results: The mean age of the obese and control groups was 44.39 ± 10.64 and 30.12 ± 8.95 years, respectively. About 46.25% of obese were men and 53.75% were women, while 42% of the control group were men and 58% were women. Serum PTH level was significantly higher (p < 0.001) among obese persons with a mean level of 53.21 ± 19.58 pg/mL for obese and 37.63 ± 21.8 pg/mL for control. Vitamin D deficiency was seen in 84.4% of the obese group while in 71.1% of the control group (p value 0.04). Females turned to have higher PTH levels than males in both the obese and the control group (p value <0.001). However, age and the presence of diabetes mellitus were not associated with higher PTH levels (p value 0.155 and 0.6, respectively). Conclusion: Obesity was associated with a higher serum PTH level related to the severity of vitamin D deficiency. |
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| issn | 2673-1797 2673-1738 |
| language | English |
| last_indexed | 2025-02-17T09:36:11Z |
| publishDate | 2021-12-01 |
| publisher | Knowledge E |
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| series | Dubai Diabetes and Endocrinology Journal |
| spelling | doaj.art-784a8efd16ac4192968e81eb414123c92025-01-02T09:35:49ZengKnowledge EDubai Diabetes and Endocrinology Journal2673-17972673-17382021-12-0127414314910.1159/000520660520660The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in BasrahMohammed Khazaal Jumaahm0Ali Hussain Ali Alhamza1Abbas Ali Mansour2https://orcid.org/0000-0001-8083-6024Department of Endocrinology, Basrah Health Directorate, Basrah, IraqDepartment of Endocrinology, Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah Health Directorate, Basrah, IraqDepartment of Endocrinology, Faiha Specialized Diabetes, Endocrine and Metabolism Center, University of Basrah, Basrah, IraqBackground: Parathyroid hormone (PTH) has been reported to have a positive correlation with insulin resistance and the development of the metabolic syndrome. This study aims to evaluate if there is an association between obesity and serum PTH levels. Methods: This case-control study was conducted at the Faiha Specialized Diabetes Endocrine and Metabolism Center in Basrah (Southern Iraq) from September 2018 to July 2019. A total of 230 patients were recruited for this study (103 male and 127 female), divided into 2 groups according to the BMI: <30 kg/m2 were considered as the control group (83 persons) and ≥30 kg/m2 were considered as obese persons (147 persons). The study groups were also subdivided into 3 groups according to the serum level of PTH: <40 pg/mL, 40–65 pg/mL, and >65 pg/mL. Results: The mean age of the obese and control groups was 44.39 ± 10.64 and 30.12 ± 8.95 years, respectively. About 46.25% of obese were men and 53.75% were women, while 42% of the control group were men and 58% were women. Serum PTH level was significantly higher (p < 0.001) among obese persons with a mean level of 53.21 ± 19.58 pg/mL for obese and 37.63 ± 21.8 pg/mL for control. Vitamin D deficiency was seen in 84.4% of the obese group while in 71.1% of the control group (p value 0.04). Females turned to have higher PTH levels than males in both the obese and the control group (p value <0.001). However, age and the presence of diabetes mellitus were not associated with higher PTH levels (p value 0.155 and 0.6, respectively). Conclusion: Obesity was associated with a higher serum PTH level related to the severity of vitamin D deficiency.https://www.karger.com/Article/FullText/520660obesityparathyroid hormonevitamin d deficiency |
| spellingShingle | Mohammed Khazaal Jumaahm Ali Hussain Ali Alhamza Abbas Ali Mansour The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah Dubai Diabetes and Endocrinology Journal obesity parathyroid hormone vitamin d deficiency |
| title | The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah |
| title_full | The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah |
| title_fullStr | The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah |
| title_full_unstemmed | The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah |
| title_short | The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah |
| title_sort | study of the association of serum parathyroid hormone level with obesity in patients admitted to a tertiary care center in basrah |
| topic | obesity parathyroid hormone vitamin d deficiency |
| url | https://www.karger.com/Article/FullText/520660 |
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