Multi-task learning for predicting synergistic drug combinations based on auto-encoding multi-relational graphs

Summary: Combinatorial drug therapy is a promising approach for treating complex diseases by combining drugs with synergistic effects. However, predicting effective drug combinations is challenging due to the complexity of biological systems and the limited understanding of pathophysiological mechan...

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Détails bibliographiques
Auteurs principaux: Wenyu Shan, Cong Shen, Lingyun Luo, Pingjian Ding
Format: Article
Langue:English
Publié: Elsevier 2023-10-01
Collection:iScience
Sujets:
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2589004223020977