Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery
Polymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/2/421 |
| _version_ | 1827653229124517888 |
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| author | Aida López Ruiz Ann Ramirez Kathleen McEnnis |
| author_facet | Aida López Ruiz Ann Ramirez Kathleen McEnnis |
| author_sort | Aida López Ruiz |
| collection | DOAJ |
| description | Polymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy. Furthermore, polymers that are sensitive to specific stimuli can be used to achieve controlled release of drugs into specific areas of the body. This review discusses the different stimuli that can be used for controlled drug delivery based on internal and external stimuli. Internal stimuli have been defined as events that evoke changes in different characteristics, inside the body, such as changes in pH, redox potential, and temperature. External stimuli have been defined as the use of an external source such as light and ultrasound to implement such changes. Special attention has been paid to the particular chemical structures that need to be incorporated into polymers to achieve the desired stimuli response. A current trend in this field is the incorporation of several stimuli in a single polymer to achieve higher specificity. Therefore, to access the most recent advances in stimuli-responsive polymers, the focus of this review is to combine several stimuli. The combination of different stimuli is discussed along with the chemical structures that can produce it. |
| first_indexed | 2024-03-09T21:14:03Z |
| format | Article |
| id | doaj.art-784b47cfe93749c3ab70ff3e0176e105 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:14:03Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-784b47cfe93749c3ab70ff3e0176e1052023-11-23T21:39:04ZengMDPI AGPharmaceutics1999-49232022-02-0114242110.3390/pharmaceutics14020421Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug DeliveryAida López Ruiz0Ann Ramirez1Kathleen McEnnis2Chemical and Materials Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102, USABiomedical Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102, USAChemical and Materials Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102, USAPolymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy. Furthermore, polymers that are sensitive to specific stimuli can be used to achieve controlled release of drugs into specific areas of the body. This review discusses the different stimuli that can be used for controlled drug delivery based on internal and external stimuli. Internal stimuli have been defined as events that evoke changes in different characteristics, inside the body, such as changes in pH, redox potential, and temperature. External stimuli have been defined as the use of an external source such as light and ultrasound to implement such changes. Special attention has been paid to the particular chemical structures that need to be incorporated into polymers to achieve the desired stimuli response. A current trend in this field is the incorporation of several stimuli in a single polymer to achieve higher specificity. Therefore, to access the most recent advances in stimuli-responsive polymers, the focus of this review is to combine several stimuli. The combination of different stimuli is discussed along with the chemical structures that can produce it.https://www.mdpi.com/1999-4923/14/2/421stimuli-responsivedrug deliverypolymer particles |
| spellingShingle | Aida López Ruiz Ann Ramirez Kathleen McEnnis Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery Pharmaceutics stimuli-responsive drug delivery polymer particles |
| title | Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery |
| title_full | Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery |
| title_fullStr | Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery |
| title_full_unstemmed | Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery |
| title_short | Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery |
| title_sort | single and multiple stimuli responsive polymer particles for controlled drug delivery |
| topic | stimuli-responsive drug delivery polymer particles |
| url | https://www.mdpi.com/1999-4923/14/2/421 |
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