Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection
Ferrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β- cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2005-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/10/6/693/ |
| _version_ | 1818611886347780096 |
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| author | Shigeori Takenaka Michinori Waki Takahiko Nojima Shinobu Sato |
| author_facet | Shigeori Takenaka Michinori Waki Takahiko Nojima Shinobu Sato |
| author_sort | Shigeori Takenaka |
| collection | DOAJ |
| description | Ferrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β- cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, and electrochemical means in the absence or presence of β-CD. Quantitative analysis by quartz crystal microbalance (QCM) and electrochemical experiments strongly suggested a 2:1 binding stoichiometry for β-CD to 1 threading-intercalated to the dsDNA-immobilized electrode. Owing to this supramolecular complex formation, electrochemical DNA detection based on 1 was improved considerably. |
| first_indexed | 2024-12-16T15:37:27Z |
| format | Article |
| id | doaj.art-7850b769df994d6c8c3ffd249c438a00 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T15:37:27Z |
| publishDate | 2005-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7850b769df994d6c8c3ffd249c438a002022-12-21T22:26:09ZengMDPI AGMolecules1420-30492005-07-0110669370710.3390/10060693Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene DetectionShigeori TakenakaMichinori WakiTakahiko NojimaShinobu SatoFerrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β- cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, and electrochemical means in the absence or presence of β-CD. Quantitative analysis by quartz crystal microbalance (QCM) and electrochemical experiments strongly suggested a 2:1 binding stoichiometry for β-CD to 1 threading-intercalated to the dsDNA-immobilized electrode. Owing to this supramolecular complex formation, electrochemical DNA detection based on 1 was improved considerably.http://www.mdpi.com/1420-3049/10/6/693/Ferrocenylnaphthalene diimideβ-cyclodextrin (CD)DNAelectrochemical detectionsupramolecular complex |
| spellingShingle | Shigeori Takenaka Michinori Waki Takahiko Nojima Shinobu Sato Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection Molecules Ferrocenylnaphthalene diimide β-cyclodextrin (CD) DNA electrochemical detection supramolecular complex |
| title | Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection |
| title_full | Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection |
| title_fullStr | Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection |
| title_full_unstemmed | Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection |
| title_short | Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection |
| title_sort | supramolecular complex formation by aza² cyclodextrin and ferrocenylnaphthalene diimide intercalated double stranded dna and improved electrochemical gene detection |
| topic | Ferrocenylnaphthalene diimide β-cyclodextrin (CD) DNA electrochemical detection supramolecular complex |
| url | http://www.mdpi.com/1420-3049/10/6/693/ |
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