Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography
The muscle index of the first vertebra (L1MI) derived from computed tomography (CT) is an indicator of total skeletal muscle mass. Nevertheless, the cutoff value and utility of L1MI derived from low-dose chest CT (LDCT) remain unclear. Adults who received LDCT for health check-ups in 2017 were enrol...
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/9/2429 |
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| author | Ping-Huai Wang Chien-Hung Gow Yen-Ling Chiu Tien-Chi Li |
| author_facet | Ping-Huai Wang Chien-Hung Gow Yen-Ling Chiu Tien-Chi Li |
| author_sort | Ping-Huai Wang |
| collection | DOAJ |
| description | The muscle index of the first vertebra (L1MI) derived from computed tomography (CT) is an indicator of total skeletal muscle mass. Nevertheless, the cutoff value and utility of L1MI derived from low-dose chest CT (LDCT) remain unclear. Adults who received LDCT for health check-ups in 2017 were enrolled. The cutoff values of L1MI were established in subjects aged 20–60 years. The cutoff values were used in chronic obstructive pulmonary disease (COPD) patients to determine muscle quantity. A total of 1780 healthy subjects were enrolled. Subjects (<i>n</i> = 1393) aged 20–60 years were defined as the reference group. The sex-specific cutoff values of L1MI were 26.2 cm<sup>2</sup>/m<sup>2</sup> for males and 20.9 cm<sup>2</sup>/m<sup>2</sup> for females. Six subjects in the COPD group (6/44, 13.6%) had low L1MI. COPD subjects with low L1MI had lower forced expiratory volume in one second (0.81 ± 0.17 vs. 1.30 ± 0.55 L/s, <i>p</i> = 0.046) and higher COPD assessment test scores (19.5 ± 2.6 vs. 15.0 ± 4.9, <i>p</i> = 0.015) than those with normal L1MI. In conclusion, LDCT in health assessments may provide additional information on sarcopenia. |
| first_indexed | 2024-03-10T04:01:29Z |
| format | Article |
| id | doaj.art-78543b85a07e4cf3859bba10e8861639 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:01:29Z |
| publishDate | 2022-04-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-78543b85a07e4cf3859bba10e88616392023-11-23T08:32:12ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01119242910.3390/jcm11092429Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed TomographyPing-Huai Wang0Chien-Hung Gow1Yen-Ling Chiu2Tien-Chi Li3Division of Pulmonology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, TaiwanDivision of Pulmonology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, TaiwanGraduate Institute of Medicine and Graduate Program in Biomedical Informatics, Yuan Ze University, Taoyuan 320, TaiwanDepartment of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, TaiwanThe muscle index of the first vertebra (L1MI) derived from computed tomography (CT) is an indicator of total skeletal muscle mass. Nevertheless, the cutoff value and utility of L1MI derived from low-dose chest CT (LDCT) remain unclear. Adults who received LDCT for health check-ups in 2017 were enrolled. The cutoff values of L1MI were established in subjects aged 20–60 years. The cutoff values were used in chronic obstructive pulmonary disease (COPD) patients to determine muscle quantity. A total of 1780 healthy subjects were enrolled. Subjects (<i>n</i> = 1393) aged 20–60 years were defined as the reference group. The sex-specific cutoff values of L1MI were 26.2 cm<sup>2</sup>/m<sup>2</sup> for males and 20.9 cm<sup>2</sup>/m<sup>2</sup> for females. Six subjects in the COPD group (6/44, 13.6%) had low L1MI. COPD subjects with low L1MI had lower forced expiratory volume in one second (0.81 ± 0.17 vs. 1.30 ± 0.55 L/s, <i>p</i> = 0.046) and higher COPD assessment test scores (19.5 ± 2.6 vs. 15.0 ± 4.9, <i>p</i> = 0.015) than those with normal L1MI. In conclusion, LDCT in health assessments may provide additional information on sarcopenia.https://www.mdpi.com/2077-0383/11/9/2429computed tomographymuscle surface indexlow muscle masslow-dose CTsarcopenia |
| spellingShingle | Ping-Huai Wang Chien-Hung Gow Yen-Ling Chiu Tien-Chi Li Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography Journal of Clinical Medicine computed tomography muscle surface index low muscle mass low-dose CT sarcopenia |
| title | Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography |
| title_full | Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography |
| title_fullStr | Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography |
| title_full_unstemmed | Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography |
| title_short | Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography |
| title_sort | determination of low muscle mass by muscle surface index of the first lumbar vertebra using low dose computed tomography |
| topic | computed tomography muscle surface index low muscle mass low-dose CT sarcopenia |
| url | https://www.mdpi.com/2077-0383/11/9/2429 |
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