Telomere maintenance: regulating hTERC fate through RNA modifications

Telomere maintenance: regulating hTERC fate through RNA modifications

Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modification...

Full description

Bibliographic Details
Main Authors: Lisa Lirussi, Hilde Nilsen
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:Molecular & Cellular Oncology
Subjects:
smug1
telomere
rna processing
hterc
cancer
base excision repair
Online Access:http://dx.doi.org/10.1080/23723556.2019.1670489
Description
Summary:Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modifications may function in a regulated process serving to fine-tune the levels of hTERC.
ISSN:2372-3556

Similar Items