Exosomes as Drug Carriers in Anti-Cancer Therapy
Over the years, there has been a high demand for developing new safe and effective drug carriers for cancer therapy. Emerging studies have indicated that exosomes can serve as potent therapeutic carriers since they offer low immunogenicity, high stability, innate and acquired targetability, and the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.728616/full |
| _version_ | 1798024939782012928 |
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| author | Lan Chen Li Wang Lingling Zhu Zihan Xu Yanyang Liu Zhixi Li Jin Zhou Feng Luo |
| author_facet | Lan Chen Li Wang Lingling Zhu Zihan Xu Yanyang Liu Zhixi Li Jin Zhou Feng Luo |
| author_sort | Lan Chen |
| collection | DOAJ |
| description | Over the years, there has been a high demand for developing new safe and effective drug carriers for cancer therapy. Emerging studies have indicated that exosomes can serve as potent therapeutic carriers since they offer low immunogenicity, high stability, innate and acquired targetability, and the stimulation of anti-cancer immune responses. Yet, the development of exosome-based drug delivery systems remains challenging due to their heterogeneity, low yield, and limited drug loading efficiency. Herein, we summarized the current application of exosomes derived from different cells as drug carriers in anti-cancer therapy in vitro and in vivo. We also discussed the challenges and prospects of exosome-based drug delivery systems in cancer therapy. |
| first_indexed | 2024-04-11T18:11:59Z |
| format | Article |
| id | doaj.art-78549f622ef748a0b8a1d41839c9765a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T18:11:59Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-78549f622ef748a0b8a1d41839c9765a2022-12-22T04:10:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-01-011010.3389/fcell.2022.728616728616Exosomes as Drug Carriers in Anti-Cancer TherapyLan Chen0Li Wang1Lingling Zhu2Zihan Xu3Yanyang Liu4Zhixi Li5Jin Zhou6Feng Luo7Lung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaLung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaLung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaLung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaLung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaLung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaSchool of Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, ChinaLung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaOver the years, there has been a high demand for developing new safe and effective drug carriers for cancer therapy. Emerging studies have indicated that exosomes can serve as potent therapeutic carriers since they offer low immunogenicity, high stability, innate and acquired targetability, and the stimulation of anti-cancer immune responses. Yet, the development of exosome-based drug delivery systems remains challenging due to their heterogeneity, low yield, and limited drug loading efficiency. Herein, we summarized the current application of exosomes derived from different cells as drug carriers in anti-cancer therapy in vitro and in vivo. We also discussed the challenges and prospects of exosome-based drug delivery systems in cancer therapy.https://www.frontiersin.org/articles/10.3389/fcell.2022.728616/fullexosomesdrug deliverycancer therapytargetabilityengineering |
| spellingShingle | Lan Chen Li Wang Lingling Zhu Zihan Xu Yanyang Liu Zhixi Li Jin Zhou Feng Luo Exosomes as Drug Carriers in Anti-Cancer Therapy Frontiers in Cell and Developmental Biology exosomes drug delivery cancer therapy targetability engineering |
| title | Exosomes as Drug Carriers in Anti-Cancer Therapy |
| title_full | Exosomes as Drug Carriers in Anti-Cancer Therapy |
| title_fullStr | Exosomes as Drug Carriers in Anti-Cancer Therapy |
| title_full_unstemmed | Exosomes as Drug Carriers in Anti-Cancer Therapy |
| title_short | Exosomes as Drug Carriers in Anti-Cancer Therapy |
| title_sort | exosomes as drug carriers in anti cancer therapy |
| topic | exosomes drug delivery cancer therapy targetability engineering |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.728616/full |
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