Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination
Coronavirus disease 2019 (COVID-19) vaccination reduces the risk of progression to severe COVID-19 in the general population. To examine that preventive effect in dialysis patients, the association of vaccination status with severe COVID-19 progression was investigated in this retrospective observat...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6348 |
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| author | Mitsuru Ichii Masafumi Kurajoh Yujiro Okute Yasutaka Ihara Takumi Imai Tomoaki Morioka Katsuhito Mori Tetsuo Shoji Yoshihiro Tsujimoto Takanobu Ubai Masanori Emoto |
| author_facet | Mitsuru Ichii Masafumi Kurajoh Yujiro Okute Yasutaka Ihara Takumi Imai Tomoaki Morioka Katsuhito Mori Tetsuo Shoji Yoshihiro Tsujimoto Takanobu Ubai Masanori Emoto |
| author_sort | Mitsuru Ichii |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) vaccination reduces the risk of progression to severe COVID-19 in the general population. To examine that preventive effect in dialysis patients, the association of vaccination status with severe COVID-19 progression was investigated in this retrospective observational study conducted from December 2020 to May 2022 of 100 such patients hospitalized for non-severe COVID-19 at Inoue Hospital (Suita, Japan). Fifty-seven were fully vaccinated, defined as receiving a COVID-19 vaccine second dose at least 14 days prior to the onset of COVID-19, while 43 were not. Among all patients, 13 (13.0%) progressed to severe COVID-19 with a median (interquartile range) time of 6 (2.5–9.5) days, while 87 (87.0%) were discharged after 11 (8–16) days. Kaplan–Meier analysis showed that fully vaccinated patients had a significantly lower rate of progression to severe COVID-19 (<i>p</i> = 0.001, log-rank test). Cox proportional hazard analysis also indicated that full COVID-19 vaccination was significantly associated with reduced instances of progression to severe COVID-19 (hazard ratio 0.104, 95% confidence interval 0.022 to 0.483; <i>p</i> = 0.004) after balancing patient background characteristics using an inverse probability of treatment weight method. These results suggest that full vaccination status contributes to reducing the risk of progression from non-severe to severe COVID-19 in dialysis patients. |
| first_indexed | 2024-03-09T18:57:41Z |
| format | Article |
| id | doaj.art-78558ae093704dfdaaa36d94cffdd7b6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:57:41Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-78558ae093704dfdaaa36d94cffdd7b62023-11-24T05:16:15ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121634810.3390/jcm11216348Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 VaccinationMitsuru Ichii0Masafumi Kurajoh1Yujiro Okute2Yasutaka Ihara3Takumi Imai4Tomoaki Morioka5Katsuhito Mori6Tetsuo Shoji7Yoshihiro Tsujimoto8Takanobu Ubai9Masanori Emoto10Division of Internal Medicine, Dialysis Center, Inoue Hospital, Suita 564-0053, JapanDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanDivision of Internal Medicine, Dialysis Center, Inoue Hospital, Suita 564-0053, JapanDepartment of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanDepartment of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanDepartment of Nephrology, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanDepartment of Vascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanDivision of Internal Medicine, Dialysis Center, Inoue Hospital, Suita 564-0053, JapanDepartment of Urology, Inoue Hospital, Suita 564-0053, JapanDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, JapanCoronavirus disease 2019 (COVID-19) vaccination reduces the risk of progression to severe COVID-19 in the general population. To examine that preventive effect in dialysis patients, the association of vaccination status with severe COVID-19 progression was investigated in this retrospective observational study conducted from December 2020 to May 2022 of 100 such patients hospitalized for non-severe COVID-19 at Inoue Hospital (Suita, Japan). Fifty-seven were fully vaccinated, defined as receiving a COVID-19 vaccine second dose at least 14 days prior to the onset of COVID-19, while 43 were not. Among all patients, 13 (13.0%) progressed to severe COVID-19 with a median (interquartile range) time of 6 (2.5–9.5) days, while 87 (87.0%) were discharged after 11 (8–16) days. Kaplan–Meier analysis showed that fully vaccinated patients had a significantly lower rate of progression to severe COVID-19 (<i>p</i> = 0.001, log-rank test). Cox proportional hazard analysis also indicated that full COVID-19 vaccination was significantly associated with reduced instances of progression to severe COVID-19 (hazard ratio 0.104, 95% confidence interval 0.022 to 0.483; <i>p</i> = 0.004) after balancing patient background characteristics using an inverse probability of treatment weight method. These results suggest that full vaccination status contributes to reducing the risk of progression from non-severe to severe COVID-19 in dialysis patients.https://www.mdpi.com/2077-0383/11/21/6348COVID-19full vaccinationsevere progressiondialysis patients |
| spellingShingle | Mitsuru Ichii Masafumi Kurajoh Yujiro Okute Yasutaka Ihara Takumi Imai Tomoaki Morioka Katsuhito Mori Tetsuo Shoji Yoshihiro Tsujimoto Takanobu Ubai Masanori Emoto Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination Journal of Clinical Medicine COVID-19 full vaccination severe progression dialysis patients |
| title | Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination |
| title_full | Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination |
| title_fullStr | Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination |
| title_full_unstemmed | Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination |
| title_short | Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination |
| title_sort | reduced risk of progression from non severe to severe covid 19 in hospitalized dialysis patients by full covid 19 vaccination |
| topic | COVID-19 full vaccination severe progression dialysis patients |
| url | https://www.mdpi.com/2077-0383/11/21/6348 |
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