COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality
Introduction: Currently, humankind is facing a COVID-19 pandemic that has spread worldwide. This is the first study conducted during the first phase of the COVID-19 outbreak in Mashhad, Iran, to describe the clinical, therapeutic, and laboratory findings of survivor and non-survivor patients with CO...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-03-01
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| Series: | Reviews in Clinical Medicine |
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| Online Access: | https://rcm.mums.ac.ir/article_22426_3e3b05be6673143710878fcad34d1d0e.pdf |
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| author | Alireza Sedaghat Amene Raouf-Rahmati Katayoun Samadi Farida Daneshvar Mozaffari Ahmad Nemati Benyamin Fazli |
| author_facet | Alireza Sedaghat Amene Raouf-Rahmati Katayoun Samadi Farida Daneshvar Mozaffari Ahmad Nemati Benyamin Fazli |
| author_sort | Alireza Sedaghat |
| collection | DOAJ |
| description | Introduction: Currently, humankind is facing a COVID-19 pandemic that has spread worldwide. This is the first study conducted during the first phase of the COVID-19 outbreak in Mashhad, Iran, to describe the clinical, therapeutic, and laboratory findings of survivor and non-survivor patients with COVID-19.Methods: This retrospective study included a total of 191 confirmed COVID-19 patients aged ≥18 who were admitted to an intensive care unit in the northeast of Iran in 2020. Clinical, therapeutic, and laboratory findings were recruited. The data were analyzed using SPSS software (version 23) through the Mann-Whitney U test, Chi-Square test, independent sample t-test, as well as a single variable and multivariable logistic regression.Results: Out of a total of 191 hospitalized patients, 137 (71.7%) survived and 54 (28.2%) expired. The mean age of non-survived patients was 17 years higher than that of survived patients (P<0.0001). Hypertension, diabetes, and coronary and pulmonary diseases were significantly related to mortality (OR: 3, 2.8, 21.4, and 5.4, respectively; P<0.05). Respiratory rate >24/min, heart rate>125/min, platelet count <100*109/L, creatinine >133 μmol/L, LDH >245 U/L, WBC count >10*109/L, lymphocyte count <0.8*109/L and D-dimer >1 μg/mL were frequently observed in non-survivor patients (P<0.05). Most of the patients had an abnormality on chest radiographs, and bilateral pulmonary infiltration was the dominant chest radiograph abnormality in these patients. Moreover, consolidation and ground-glass opacification were observed more frequently in non-survived patients (P<0.05). More than 57% of severe cases required non-invasive and invasive mechanical ventilation before they died, while it was 1% in survived cases (P<0.05).Conclusion: Older age, previous comorbidities such as diabetes, hypertension, coronary and pulmonary diseases, lymphopenia, leukocytosis, increased respiratory rate, creatinine, LDH, and D-dimer levels were related to a poor prognosis and mortality in patients with SARS-CoV-2 infection. |
| first_indexed | 2024-03-11T16:07:20Z |
| format | Article |
| id | doaj.art-7857a312b38943938ac7a4053be82675 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-03-11T16:07:20Z |
| publishDate | 2023-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-7857a312b38943938ac7a4053be826752023-10-24T19:28:18ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922023-03-01101334010.22038/rcm.2023.71483.144522426COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with MortalityAlireza Sedaghat0Amene Raouf-Rahmati1Katayoun Samadi2Farida Daneshvar Mozaffari3Ahmad Nemati4Benyamin Fazli5Lung disease research center, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Kidney Transplantation Complications Research Center, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranAnesthesiologist, Department of aneshthesiology, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, IranMD , Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant professor of Intensive Care medicine, Department of aneshthesiology, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, IranIntroduction: Currently, humankind is facing a COVID-19 pandemic that has spread worldwide. This is the first study conducted during the first phase of the COVID-19 outbreak in Mashhad, Iran, to describe the clinical, therapeutic, and laboratory findings of survivor and non-survivor patients with COVID-19.Methods: This retrospective study included a total of 191 confirmed COVID-19 patients aged ≥18 who were admitted to an intensive care unit in the northeast of Iran in 2020. Clinical, therapeutic, and laboratory findings were recruited. The data were analyzed using SPSS software (version 23) through the Mann-Whitney U test, Chi-Square test, independent sample t-test, as well as a single variable and multivariable logistic regression.Results: Out of a total of 191 hospitalized patients, 137 (71.7%) survived and 54 (28.2%) expired. The mean age of non-survived patients was 17 years higher than that of survived patients (P<0.0001). Hypertension, diabetes, and coronary and pulmonary diseases were significantly related to mortality (OR: 3, 2.8, 21.4, and 5.4, respectively; P<0.05). Respiratory rate >24/min, heart rate>125/min, platelet count <100*109/L, creatinine >133 μmol/L, LDH >245 U/L, WBC count >10*109/L, lymphocyte count <0.8*109/L and D-dimer >1 μg/mL were frequently observed in non-survivor patients (P<0.05). Most of the patients had an abnormality on chest radiographs, and bilateral pulmonary infiltration was the dominant chest radiograph abnormality in these patients. Moreover, consolidation and ground-glass opacification were observed more frequently in non-survived patients (P<0.05). More than 57% of severe cases required non-invasive and invasive mechanical ventilation before they died, while it was 1% in survived cases (P<0.05).Conclusion: Older age, previous comorbidities such as diabetes, hypertension, coronary and pulmonary diseases, lymphopenia, leukocytosis, increased respiratory rate, creatinine, LDH, and D-dimer levels were related to a poor prognosis and mortality in patients with SARS-CoV-2 infection.https://rcm.mums.ac.ir/article_22426_3e3b05be6673143710878fcad34d1d0e.pdfcovid-19coronaviressars-cov-2iranmortality |
| spellingShingle | Alireza Sedaghat Amene Raouf-Rahmati Katayoun Samadi Farida Daneshvar Mozaffari Ahmad Nemati Benyamin Fazli COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality Reviews in Clinical Medicine covid-19 coronavires sars-cov-2 iran mortality |
| title | COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality |
| title_full | COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality |
| title_fullStr | COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality |
| title_full_unstemmed | COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality |
| title_short | COVID-19 in Iran: Clinical, Therapeutic, and Laboratory Findings Associated with Mortality |
| title_sort | covid 19 in iran clinical therapeutic and laboratory findings associated with mortality |
| topic | covid-19 coronavires sars-cov-2 iran mortality |
| url | https://rcm.mums.ac.ir/article_22426_3e3b05be6673143710878fcad34d1d0e.pdf |
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