Glypican-3: A Novel and Promising Target for the Treatment of Hepatocellular Carcinoma

Glypican-3: A Novel and Promising Target for the Treatment of Hepatocellular Carcinoma

Glypican-3 (GPC3) is a membrane-associated proteoglycan that is specifically up-regulated in hepatocellular carcinoma (HCC) although rarely or not expressed in normal liver tissues, making it a perfect diagnostic and treatment target for HCC. Several GPC3-based clinical trials are ongoing and recent...

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Bibliographic Details
Main Authors:	Xiufeng Zheng, Xun Liu, Yanna Lei, Gang Wang, Ming Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-02-01
Series:	Frontiers in Oncology
Subjects:	glypican-3 (GPC3) hepatocellular carcinoma (HCC) cancer immunotherapy immune checkpoint blockade chimeric antigen receptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.824208/full

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