The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer
Bladder cancer is one of the most common malignancies of the urinary tract and can be divided into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Although the means of diagnosis and treatment have continually improved in recent years, the recurrence rate of bla...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/4/1007 |
| _version_ | 1797621933591756800 |
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| author | Hao Wang Yanfei Feng Xiangyi Zheng Xin Xu |
| author_facet | Hao Wang Yanfei Feng Xiangyi Zheng Xin Xu |
| author_sort | Hao Wang |
| collection | DOAJ |
| description | Bladder cancer is one of the most common malignancies of the urinary tract and can be divided into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Although the means of diagnosis and treatment have continually improved in recent years, the recurrence rate of bladder cancer remains high, and patients with MIBC typically have an unfavourable prognosis and a low quality of life. Emerging evidence demonstrates that long noncoding RNAs play a crucial role in the carcinogenesis and progression of bladder cancer. Long intergenic noncoding RNAs (lincRNAs) are a subgroup of long noncoding RNAs (lncRNAs) that do not overlap protein-coding genes. The potential role of lincRNAs in the regulation of gene expression has been explored in depth in recent years. Small nucleolar RNAs (snoRNAs) are a class of noncoding RNAs (ncRNAs) that mainly exist in the nucleolus, are approximately 60–300 nucleotides in length, and are hosted inside the introns of genes. Small nucleolar RNA host genes (SNHGs) have been associated with the origin and development of bladder cancer. In this review, we aim to comprehensively summarize the biological functions of these molecules in bladder cancer. |
| first_indexed | 2024-03-11T09:03:05Z |
| format | Article |
| id | doaj.art-7859f7a74f9044a9933b2116972cda4a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:03:05Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7859f7a74f9044a9933b2116972cda4a2023-11-16T19:34:46ZengMDPI AGCancers2072-66942023-02-01154100710.3390/cancers15041007The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder CancerHao Wang0Yanfei Feng1Xiangyi Zheng2Xin Xu3Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaSecond Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaBladder cancer is one of the most common malignancies of the urinary tract and can be divided into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Although the means of diagnosis and treatment have continually improved in recent years, the recurrence rate of bladder cancer remains high, and patients with MIBC typically have an unfavourable prognosis and a low quality of life. Emerging evidence demonstrates that long noncoding RNAs play a crucial role in the carcinogenesis and progression of bladder cancer. Long intergenic noncoding RNAs (lincRNAs) are a subgroup of long noncoding RNAs (lncRNAs) that do not overlap protein-coding genes. The potential role of lincRNAs in the regulation of gene expression has been explored in depth in recent years. Small nucleolar RNAs (snoRNAs) are a class of noncoding RNAs (ncRNAs) that mainly exist in the nucleolus, are approximately 60–300 nucleotides in length, and are hosted inside the introns of genes. Small nucleolar RNA host genes (SNHGs) have been associated with the origin and development of bladder cancer. In this review, we aim to comprehensively summarize the biological functions of these molecules in bladder cancer.https://www.mdpi.com/2072-6694/15/4/1007bladder cancersmall nucleolar RNAlong intergenic noncoding RNA |
| spellingShingle | Hao Wang Yanfei Feng Xiangyi Zheng Xin Xu The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer Cancers bladder cancer small nucleolar RNA long intergenic noncoding RNA |
| title | The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer |
| title_full | The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer |
| title_fullStr | The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer |
| title_full_unstemmed | The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer |
| title_short | The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer |
| title_sort | diagnostic and therapeutic role of snorna and lincrna in bladder cancer |
| topic | bladder cancer small nucleolar RNA long intergenic noncoding RNA |
| url | https://www.mdpi.com/2072-6694/15/4/1007 |
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