Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites
Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for th...
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| Format: | Article |
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MDPI AG
2019-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/1/263 |
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| author | Shara Francesca Rapa Biagio Raffaele Di Iorio Pietro Campiglia August Heidland Stefania Marzocco |
| author_facet | Shara Francesca Rapa Biagio Raffaele Di Iorio Pietro Campiglia August Heidland Stefania Marzocco |
| author_sort | Shara Francesca Rapa |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary. |
| first_indexed | 2024-04-12T19:14:45Z |
| format | Article |
| id | doaj.art-785af3017f4742efbc6e6764664d62db |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T19:14:45Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-785af3017f4742efbc6e6764664d62db2022-12-22T03:19:46ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-12-0121126310.3390/ijms21010263ijms21010263Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived MetabolitesShara Francesca Rapa0Biagio Raffaele Di Iorio1Pietro Campiglia2August Heidland3Stefania Marzocco4Department of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, ItalyUOC Nephrology AORN “San Giuseppe Moscati”, C.da Amoretta, 83100 Avellino, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, ItalyDepartment of Internal Medicine and KfH Kidney Center, University of Würzburg, KfH Kidney Center Würzburg, 97080 Würzburg, GermanyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, ItalyChronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.https://www.mdpi.com/1422-0067/21/1/263chronic kidney disease (ckd)inflammationoxidative stressuremic toxinsmineralsvitaminsplant-derived metabolites |
| spellingShingle | Shara Francesca Rapa Biagio Raffaele Di Iorio Pietro Campiglia August Heidland Stefania Marzocco Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites International Journal of Molecular Sciences chronic kidney disease (ckd) inflammation oxidative stress uremic toxins minerals vitamins plant-derived metabolites |
| title | Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites |
| title_full | Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites |
| title_fullStr | Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites |
| title_full_unstemmed | Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites |
| title_short | Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites |
| title_sort | inflammation and oxidative stress in chronic kidney disease potential therapeutic role of minerals vitamins and plant derived metabolites |
| topic | chronic kidney disease (ckd) inflammation oxidative stress uremic toxins minerals vitamins plant-derived metabolites |
| url | https://www.mdpi.com/1422-0067/21/1/263 |
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