Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila

Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila

Bibliographic Details
Main Authors:	Xiao Li, Meng Zhang, Mengmeng Liu, Tzu-Hao Liu, Rajitha-Udakara-Sampath Hemba-Waduge, Jun-Yuan Ji
Format:	Article
Language:	English
Published:	The Company of Biologists 2022-11-01
Series:	Disease Models & Mechanisms
Subjects:	cdk8 srebp lipogenesis mediator complex drosophila
Online Access:	http://dmm.biologists.org/content/15/11/dmm049650

Similar Items

RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression
by: Di Guo, et al.
Published: (2019-05-01)

Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
by: Qiushi Zhao, et al.
Published: (2022-07-01)

The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway
by: Yuhong Huang, et al.
Published: (2024-01-01)

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
by: Han Zeng, et al.
Published: (2022-03-01)

Histone Deacetylase 1 Reduces Lipogenesis by Suppressing SREBP1 Transcription in Human Sebocyte Cell Line SZ95
by: Hye Sun Shin, et al.
Published: (2021-04-01)

Expression levels of genes involved in lipogenesis and cholesterol synthesis in adenomyosis
by: Yalaza Cem, et al.
Published: (2024-01-01)

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies
by: Na Li, et al.
Published: (2023-12-01)

Dexamethasone potentiates the insulin-induced Srebp-1c expression in primary rat hepatocytes
by: Yan Zhang, et al.
Published: (2023-09-01)

Ganoderma tsugae Inhibits the SREBP-1/AR Axis Leading to Suppression of Cell Growth and Activation of Apoptosis in Prostate Cancer Cells
by: Shih-Yin Huang, et al.
Published: (2018-10-01)

CDK8-Novel Therapeutic Opportunities
by: Ingeborg Menzl, et al.
Published: (2019-06-01)

The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis
by: Preethi Chandrasekaran, et al.
Published: (2024-01-01)

The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis
by: Arwa Aldaalis, et al.
Published: (2022-08-01)

Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA
by: Pan Hu, et al.
Published: (2023-12-01)

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
by: Marius Volker Dannappel, et al.
Published: (2019-01-01)

Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs
by: Shereen A. El Sobky, et al.
Published: (2022-09-01)

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin
by: Takashi Yamamoto, et al.
Published: (2010-07-01)

The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice
by: Takayasu Ideta, et al.
Published: (2015-12-01)

4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor
by: Ofer Moldavski, et al.
Published: (2021-01-01)

Emerging Therapeutic Activity of <i>Davallia formosana</i> on Prostate Cancer Cells through Coordinated Blockade of Lipogenesis and Androgen Receptor Expression
by: Po-Fan Hsieh, et al.
Published: (2020-04-01)

Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women
by: Jing Yang, et al.
Published: (2020-11-01)

Diphlorethohydroxycarmalol Attenuates Palmitate-Induced Hepatic Lipogenesis and Inflammation
by: Seon-Heui Cha, et al.
Published: (2020-09-01)

Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells
by: Zhou Bing-rong, et al.
Published: (2012-11-01)

The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription.
by: Xiao Li, et al.
Published: (2020-05-01)

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
by: Shunxing Rong, et al.
Published: (2017-02-01)

Distinct and Overlapping Requirements for Cyclins A, B, and B3 in Drosophila Female Meiosis
by: Mohammed Bourouh, et al.
Published: (2016-11-01)

Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study
by: Yen-Chung Lin, et al.
Published: (2020-06-01)

Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 Signaling and Counteracts Ovariectomy-Induced Osteoporosis
by: Chao Jiang, et al.
Published: (2021-05-01)

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells
by: Phuriwat Khiewkamrop, et al.
Published: (2022-05-01)

Identifying Cancers Impacted by CDK8/19
by: Igor B. Roninson, et al.
Published: (2019-08-01)

Cdk8 and Ssn801 Regulate Oxidative Stress Resistance and Virulence in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>
by: Andrew L. Chang, et al.
Published: (2019-02-01)

Corrigendum: Oxymatrine attenuates osteoclastogenesis via modulation of ROS-mediated SREBP2 signaling and counteracts ovariectomy-induced osteoporosis
by: Chao Jiang, et al.
Published: (2022-09-01)

The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs
by: Amanda C. Sharko, et al.
Published: (2021-01-01)

Hypolipidemic activity of Dracocephalum kotschyi involves FOXO1 mediated modulation of PPARγ expression in adipocytes
by: Shima Aslian, et al.
Published: (2018-10-01)

Concomitant Inhibition of FASN and SREBP Provides a Promising Therapy for CTCL
by: Cheng Chi, et al.
Published: (2022-09-01)

Key events in cancer: Dysregulation of SREBPs
by: Yunkuo Li, et al.
Published: (2023-03-01)

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models
by: Youying Zhang, et al.
Published: (2017-06-01)

SREBPs as the potential target for solving the polypharmacy dilemma
by: Xue Wang, et al.
Published: (2024-01-01)

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
by: Nian Yang, et al.
Published: (2019-06-01)

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis
by: Xin Zhou, et al.
Published: (2021-05-01)

Signal Integration by Cyclin-Dependent Kinase 8 (CDK8) Module and Other Mediator Subunits in Biotic and Abiotic Stress Responses
by: Leelyn Chong, et al.
Published: (2020-12-01)