Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application

Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application

Immune checkpoint inhibitors (ICI) have emerged as a powerful oncologic treatment modality for patients with different solid tumors. Unfortunately, the efficacy of ICI monotherapy in ovarian cancer is limited, and combination therapy provides a new opportunity for immunotherapy in ovarian cancer. DN...

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Bibliographic Details
Main Authors: Hongyu Xie, Wenjie Wang, Wencai Qi, Weilin Jin, Bairong Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
ovarian cancer
DNA damage response
PARP inhibitors
combination therapy
immune checkpoint inhibitors (ICI)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661115/full

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