Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea
Background: There are limited data about the racial difference in the characteristics of chronic obstructive pulmonary disease (COPD) patients who are treated at clinics. We aimed to compare sociodemographic and clinical characteristics between US and Korean COPD patients using large-scale nationwid...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-01-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/2040622320982455 |
| _version_ | 1818452148371849216 |
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| author | Hye Yun Park Hyun Lee Danbee Kang Hye Sook Choi Yeong Ha Ryu Ki-Suck Jung Don D. Sin Juhee Cho Kwang Ha Yoo |
| author_facet | Hye Yun Park Hyun Lee Danbee Kang Hye Sook Choi Yeong Ha Ryu Ki-Suck Jung Don D. Sin Juhee Cho Kwang Ha Yoo |
| author_sort | Hye Yun Park |
| collection | DOAJ |
| description | Background: There are limited data about the racial difference in the characteristics of chronic obstructive pulmonary disease (COPD) patients who are treated at clinics. We aimed to compare sociodemographic and clinical characteristics between US and Korean COPD patients using large-scale nationwide COPD cohorts. Methods: We used the baseline demographic and clinical data of COPD patients aged 45 years or older with at least a 10 pack-per year smoking history from the Korean COPD Subtype Study (KOCOSS, n = 1686) cohort (2012–2018) and phase I (2008–2011) of the US Genetic Epidemiology of COPD (COPDGene) study ( n = 4477, 3461 were non-Hispanic whites [NHW], and 1016 were African Americans [AA]). Results: Compared to NHW, AA had a significantly lower adjusted prevalence ratio (aPR) of cough >3 months (aPR: 0.67; 95% CI [confidence interval]: 0.60–0.75) and phlegm >3 months (aPR: 0.78, 95% CI: 0.70–0.86), but higher aPR of dyspnea (modified Medical Round Council scale ⩾2) (aPR: 1.22; 95% CI: 1.15–1.29), short six-minute walk distance (<350 m) (aPR: 1.98; 95% CI: 1.81–2.14), and poor quality of life (aPR: 1.10; 95% CI: 1.05–1.15). Compared to NHW, Koreans had a significantly lower aPR of cough >3 months (aPR: 0.53; 95% CI: 0.47–0.59), phlegm >3 months (aPR: 0.75; 95% CI: 0.67–0.82), dyspnea (aPR: 0.72; 95% CI: 0.66–0.79), and moderate-to-severe acute exacerbation in the previous year (aPR: 0.73; 95% CI: 0.65–0.82). NHW had the highest burden related to chronic bronchitis symptoms and cardiovascular diseases related to comorbidities. Conclusion: There are substantial differences in sociodemographic characteristics, clinical presentation, and comorbidities between COPD patients from the KOCOSS and COPDGene, which might be caused by interactions between various intrapersonal, interpersonal, and environmental factors of the ecological model. Thus, a broader and more comprehensive approach would be necessary to understand the racial differences of COPD patients. |
| first_indexed | 2024-12-14T21:18:29Z |
| format | Article |
| id | doaj.art-785cc6df3ee64d03bd1f8f1db2544f81 |
| institution | Directory Open Access Journal |
| issn | 2040-6231 |
| language | English |
| last_indexed | 2024-12-14T21:18:29Z |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj.art-785cc6df3ee64d03bd1f8f1db2544f812022-12-21T22:47:00ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312021-01-011210.1177/2040622320982455Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and KoreaHye Yun ParkHyun LeeDanbee KangHye Sook ChoiYeong Ha RyuKi-Suck JungDon D. SinJuhee ChoKwang Ha YooBackground: There are limited data about the racial difference in the characteristics of chronic obstructive pulmonary disease (COPD) patients who are treated at clinics. We aimed to compare sociodemographic and clinical characteristics between US and Korean COPD patients using large-scale nationwide COPD cohorts. Methods: We used the baseline demographic and clinical data of COPD patients aged 45 years or older with at least a 10 pack-per year smoking history from the Korean COPD Subtype Study (KOCOSS, n = 1686) cohort (2012–2018) and phase I (2008–2011) of the US Genetic Epidemiology of COPD (COPDGene) study ( n = 4477, 3461 were non-Hispanic whites [NHW], and 1016 were African Americans [AA]). Results: Compared to NHW, AA had a significantly lower adjusted prevalence ratio (aPR) of cough >3 months (aPR: 0.67; 95% CI [confidence interval]: 0.60–0.75) and phlegm >3 months (aPR: 0.78, 95% CI: 0.70–0.86), but higher aPR of dyspnea (modified Medical Round Council scale ⩾2) (aPR: 1.22; 95% CI: 1.15–1.29), short six-minute walk distance (<350 m) (aPR: 1.98; 95% CI: 1.81–2.14), and poor quality of life (aPR: 1.10; 95% CI: 1.05–1.15). Compared to NHW, Koreans had a significantly lower aPR of cough >3 months (aPR: 0.53; 95% CI: 0.47–0.59), phlegm >3 months (aPR: 0.75; 95% CI: 0.67–0.82), dyspnea (aPR: 0.72; 95% CI: 0.66–0.79), and moderate-to-severe acute exacerbation in the previous year (aPR: 0.73; 95% CI: 0.65–0.82). NHW had the highest burden related to chronic bronchitis symptoms and cardiovascular diseases related to comorbidities. Conclusion: There are substantial differences in sociodemographic characteristics, clinical presentation, and comorbidities between COPD patients from the KOCOSS and COPDGene, which might be caused by interactions between various intrapersonal, interpersonal, and environmental factors of the ecological model. Thus, a broader and more comprehensive approach would be necessary to understand the racial differences of COPD patients.https://doi.org/10.1177/2040622320982455 |
| spellingShingle | Hye Yun Park Hyun Lee Danbee Kang Hye Sook Choi Yeong Ha Ryu Ki-Suck Jung Don D. Sin Juhee Cho Kwang Ha Yoo Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea Therapeutic Advances in Chronic Disease |
| title | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
| title_full | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
| title_fullStr | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
| title_full_unstemmed | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
| title_short | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
| title_sort | understanding racial differences of copd patients with an ecological model two large cohort studies in the us and korea |
| url | https://doi.org/10.1177/2040622320982455 |
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