Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy
Hydrogen sulfide (H<sub>2</sub>S) belongs to the family of gasotransmitters and can modulate a myriad of biological signaling pathways. Among others, its cardioprotective effects, through antioxidant, anti-inflammatory, anti-fibrotic, and proangiogenic activities, are well-documented in...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/13/2/158 |
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| author | Agnieszka Łoboda Józef Dulak |
| author_facet | Agnieszka Łoboda Józef Dulak |
| author_sort | Agnieszka Łoboda |
| collection | DOAJ |
| description | Hydrogen sulfide (H<sub>2</sub>S) belongs to the family of gasotransmitters and can modulate a myriad of biological signaling pathways. Among others, its cardioprotective effects, through antioxidant, anti-inflammatory, anti-fibrotic, and proangiogenic activities, are well-documented in experimental studies. Cardiorespiratory failure, predominantly cardiomyopathy, is a life-threatening complication that is the number one cause of death in patients with Duchenne muscular dystrophy (DMD). Although recent data suggest the role of H<sub>2</sub>S in ameliorating muscle wasting in murine and <i>Caenorhabditis elegans</i> models of DMD, possible cardioprotective effects have not yet been addressed. In this review, we summarize the current understanding of the role of H<sub>2</sub>S in animal models of cardiac dysfunctions and cardiac cells. We highlight that DMD may be amenable to H<sub>2</sub>S supplementation, and we suggest H<sub>2</sub>S as a possible factor regulating DMD-associated cardiomyopathy. |
| first_indexed | 2024-03-08T09:55:53Z |
| format | Article |
| id | doaj.art-785f69969ced42ea97dc25f43a6ddab0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T09:55:53Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-785f69969ced42ea97dc25f43a6ddab02024-01-29T13:50:27ZengMDPI AGCells2073-44092024-01-0113215810.3390/cells13020158Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy CardiomyopathyAgnieszka Łoboda0Józef Dulak1Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7 Street, 30-387 Kraków, PolandDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7 Street, 30-387 Kraków, PolandHydrogen sulfide (H<sub>2</sub>S) belongs to the family of gasotransmitters and can modulate a myriad of biological signaling pathways. Among others, its cardioprotective effects, through antioxidant, anti-inflammatory, anti-fibrotic, and proangiogenic activities, are well-documented in experimental studies. Cardiorespiratory failure, predominantly cardiomyopathy, is a life-threatening complication that is the number one cause of death in patients with Duchenne muscular dystrophy (DMD). Although recent data suggest the role of H<sub>2</sub>S in ameliorating muscle wasting in murine and <i>Caenorhabditis elegans</i> models of DMD, possible cardioprotective effects have not yet been addressed. In this review, we summarize the current understanding of the role of H<sub>2</sub>S in animal models of cardiac dysfunctions and cardiac cells. We highlight that DMD may be amenable to H<sub>2</sub>S supplementation, and we suggest H<sub>2</sub>S as a possible factor regulating DMD-associated cardiomyopathy.https://www.mdpi.com/2073-4409/13/2/158Duchenne muscular dystrophyDMDcardiomyopathyiPSC-CMinduced pluripotent stem cell-derived cardiomyocyteshydrogen sulfide |
| spellingShingle | Agnieszka Łoboda Józef Dulak Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy Cells Duchenne muscular dystrophy DMD cardiomyopathy iPSC-CM induced pluripotent stem cell-derived cardiomyocytes hydrogen sulfide |
| title | Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy |
| title_full | Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy |
| title_fullStr | Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy |
| title_full_unstemmed | Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy |
| title_short | Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy |
| title_sort | cardioprotective effects of hydrogen sulfide and its potential therapeutic implications in the amelioration of duchenne muscular dystrophy cardiomyopathy |
| topic | Duchenne muscular dystrophy DMD cardiomyopathy iPSC-CM induced pluripotent stem cell-derived cardiomyocytes hydrogen sulfide |
| url | https://www.mdpi.com/2073-4409/13/2/158 |
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