From Animaculum to single molecules: 300 years of the light microscope
Although not laying claim to being the inventor of the light microscope, Antonj van Leeuwenhoek (1632–1723) was arguably the first person to bring this new technological wonder of the age properly to the attention of natural scientists interested in the study of living things (people we might now te...
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Format: | Article |
Language: | English |
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The Royal Society
2015-01-01
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Series: | Open Biology |
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Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150019 |
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author | Adam J. M. Wollman Richard Nudd Erik G. Hedlund Mark C. Leake |
author_facet | Adam J. M. Wollman Richard Nudd Erik G. Hedlund Mark C. Leake |
author_sort | Adam J. M. Wollman |
collection | DOAJ |
description | Although not laying claim to being the inventor of the light microscope, Antonj van Leeuwenhoek (1632–1723) was arguably the first person to bring this new technological wonder of the age properly to the attention of natural scientists interested in the study of living things (people we might now term ‘biologists’). He was a Dutch draper with no formal scientific training. From using magnifying glasses to observe threads in cloth, he went on to develop over 500 simple single lens microscopes (Baker & Leeuwenhoek 1739 Phil. Trans. 41, 503–519. (doi:10.1098/rstl.1739.0085)) which he used to observe many different biological samples. He communicated his finding to the Royal Society in a series of letters (Leeuwenhoek 1800 The select works of Antony Van Leeuwenhoek, containing his microscopical discoveries in many of the works of nature, vol. 1) including the one republished in this edition of Open Biology. Our review here begins with the work of van Leeuwenhoek before summarizing the key developments over the last ca 300 years, which has seen the light microscope evolve from a simple single lens device of van Leeuwenhoek's day into an instrument capable of observing the dynamics of single biological molecules inside living cells, and to tracking every cell nucleus in the development of whole embryos and plants. |
first_indexed | 2024-04-13T15:00:05Z |
format | Article |
id | doaj.art-785fadc9c80a4b0dbcec095ffa41deca |
institution | Directory Open Access Journal |
issn | 2046-2441 |
language | English |
last_indexed | 2024-04-13T15:00:05Z |
publishDate | 2015-01-01 |
publisher | The Royal Society |
record_format | Article |
series | Open Biology |
spelling | doaj.art-785fadc9c80a4b0dbcec095ffa41deca2022-12-22T02:42:18ZengThe Royal SocietyOpen Biology2046-24412015-01-015410.1098/rsob.150019150019From Animaculum to single molecules: 300 years of the light microscopeAdam J. M. WollmanRichard NuddErik G. HedlundMark C. LeakeAlthough not laying claim to being the inventor of the light microscope, Antonj van Leeuwenhoek (1632–1723) was arguably the first person to bring this new technological wonder of the age properly to the attention of natural scientists interested in the study of living things (people we might now term ‘biologists’). He was a Dutch draper with no formal scientific training. From using magnifying glasses to observe threads in cloth, he went on to develop over 500 simple single lens microscopes (Baker & Leeuwenhoek 1739 Phil. Trans. 41, 503–519. (doi:10.1098/rstl.1739.0085)) which he used to observe many different biological samples. He communicated his finding to the Royal Society in a series of letters (Leeuwenhoek 1800 The select works of Antony Van Leeuwenhoek, containing his microscopical discoveries in many of the works of nature, vol. 1) including the one republished in this edition of Open Biology. Our review here begins with the work of van Leeuwenhoek before summarizing the key developments over the last ca 300 years, which has seen the light microscope evolve from a simple single lens device of van Leeuwenhoek's day into an instrument capable of observing the dynamics of single biological molecules inside living cells, and to tracking every cell nucleus in the development of whole embryos and plants.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150019optical microscopysuperresolutionfluorescence |
spellingShingle | Adam J. M. Wollman Richard Nudd Erik G. Hedlund Mark C. Leake From Animaculum to single molecules: 300 years of the light microscope Open Biology optical microscopy superresolution fluorescence |
title | From Animaculum to single molecules: 300 years of the light microscope |
title_full | From Animaculum to single molecules: 300 years of the light microscope |
title_fullStr | From Animaculum to single molecules: 300 years of the light microscope |
title_full_unstemmed | From Animaculum to single molecules: 300 years of the light microscope |
title_short | From Animaculum to single molecules: 300 years of the light microscope |
title_sort | from animaculum to single molecules 300 years of the light microscope |
topic | optical microscopy superresolution fluorescence |
url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150019 |
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