Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique
Resveratrol has proven antioxidant, anticancer, anti-inflammatory and cardioprotective effects. However, poor water solubility, low bioavailability and UV light sensitivity hinder its usage in food applications. Encapsulation of resveratrol can help to overcome these problems. In this work, encapsul...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619301847 |
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| author | Heera Jayan M. Maria Leena S.K. Sivakama Sundari J.A. Moses C. Anandharamakrishnan |
| author_facet | Heera Jayan M. Maria Leena S.K. Sivakama Sundari J.A. Moses C. Anandharamakrishnan |
| author_sort | Heera Jayan |
| collection | DOAJ |
| description | Resveratrol has proven antioxidant, anticancer, anti-inflammatory and cardioprotective effects. However, poor water solubility, low bioavailability and UV light sensitivity hinder its usage in food applications. Encapsulation of resveratrol can help to overcome these problems. In this work, encapsulation by electrospraying was adopted, owing to the possibility of obtaining spherical and nano-sized particles at room temperature. This study proved that resveratrol can be efficiently encapsulated with zein without modifying its native form. Size of nanoencapsulated particles obtained ranged from 230 to 330 nm. Nanoencapsulation through electrospraying process yielded 68.49% encapsulation efficiency at 1:50 resveratrol to zein w/w%. Further, nanoencapsulated resveratrol showed better stability and sustained release profiles as compared to the unencapsulated form. Nanoencapsulation with zein protected resveratrol in simulated stomach conditions and released resveratrol in the intestinal condition. Additionally, nanoencapsulated resveratrol showed increased permeability of 1.15 fold in ex-vivo dynamic engineered small intestinal system which in turn relates to improved bioavailability. Prepared nanoparticles can be used for oral administration by incorporation into food products or in tablet form. |
| first_indexed | 2024-12-20T01:06:35Z |
| format | Article |
| id | doaj.art-786036852e3d4ceea04f03088cad5a2a |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T01:06:35Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-786036852e3d4ceea04f03088cad5a2a2022-12-21T19:58:50ZengElsevierJournal of Functional Foods1756-46462019-06-0157417424Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying techniqueHeera Jayan0M. Maria Leena1S.K. Sivakama Sundari2J.A. Moses3C. Anandharamakrishnan4Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India, Pudukkottai Road, Thanjavur 613005, IndiaComputational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India, Pudukkottai Road, Thanjavur 613005, IndiaComputational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India, Pudukkottai Road, Thanjavur 613005, IndiaComputational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India, Pudukkottai Road, Thanjavur 613005, IndiaCorresponding author.; Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India, Pudukkottai Road, Thanjavur 613005, IndiaResveratrol has proven antioxidant, anticancer, anti-inflammatory and cardioprotective effects. However, poor water solubility, low bioavailability and UV light sensitivity hinder its usage in food applications. Encapsulation of resveratrol can help to overcome these problems. In this work, encapsulation by electrospraying was adopted, owing to the possibility of obtaining spherical and nano-sized particles at room temperature. This study proved that resveratrol can be efficiently encapsulated with zein without modifying its native form. Size of nanoencapsulated particles obtained ranged from 230 to 330 nm. Nanoencapsulation through electrospraying process yielded 68.49% encapsulation efficiency at 1:50 resveratrol to zein w/w%. Further, nanoencapsulated resveratrol showed better stability and sustained release profiles as compared to the unencapsulated form. Nanoencapsulation with zein protected resveratrol in simulated stomach conditions and released resveratrol in the intestinal condition. Additionally, nanoencapsulated resveratrol showed increased permeability of 1.15 fold in ex-vivo dynamic engineered small intestinal system which in turn relates to improved bioavailability. Prepared nanoparticles can be used for oral administration by incorporation into food products or in tablet form.http://www.sciencedirect.com/science/article/pii/S1756464619301847NanoencapsulationResveratrolElectrosprayingSustained releaseBioavailability |
| spellingShingle | Heera Jayan M. Maria Leena S.K. Sivakama Sundari J.A. Moses C. Anandharamakrishnan Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique Journal of Functional Foods Nanoencapsulation Resveratrol Electrospraying Sustained release Bioavailability |
| title | Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique |
| title_full | Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique |
| title_fullStr | Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique |
| title_full_unstemmed | Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique |
| title_short | Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique |
| title_sort | improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique |
| topic | Nanoencapsulation Resveratrol Electrospraying Sustained release Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619301847 |
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