Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals
HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, which will be reviewed here, indicates that r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/12/1484 |
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| author | Yonas Bekele Jay A. Berzofsky Francesca Chiodi |
| author_facet | Yonas Bekele Jay A. Berzofsky Francesca Chiodi |
| author_sort | Yonas Bekele |
| collection | DOAJ |
| description | HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, which will be reviewed here, indicates that response to HBV vaccine is suboptimal in HIV-1-infected individuals and that the poor maintenance of protective immunity to HBV vaccines in these individuals is an important medical issue. Several factors affect HBV vaccine response during HIV-1 infection including CD4+ T cell counts, B cell response, vaccine formulation, schedules, and timing of antiretroviral therapy (ART). The initial response to HBV vaccination also plays a critical role in the sustainability of antibody responses in both HIV-1-infected and uninfected vaccinees. Thus, regular follow-up for antibody titer and a booster dose is warranted to prevent HBV transmission in HIV-1 infected people. |
| first_indexed | 2024-03-10T03:56:10Z |
| format | Article |
| id | doaj.art-78607141cc264d8a8b3f51e344ce6234 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T03:56:10Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-78607141cc264d8a8b3f51e344ce62342023-11-23T10:54:59ZengMDPI AGVaccines2076-393X2021-12-01912148410.3390/vaccines9121484Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected IndividualsYonas Bekele0Jay A. Berzofsky1Francesca Chiodi2Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USAVaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USADepartment of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Solnavägen 9, 17165 Solna, SwedenHBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, which will be reviewed here, indicates that response to HBV vaccine is suboptimal in HIV-1-infected individuals and that the poor maintenance of protective immunity to HBV vaccines in these individuals is an important medical issue. Several factors affect HBV vaccine response during HIV-1 infection including CD4+ T cell counts, B cell response, vaccine formulation, schedules, and timing of antiretroviral therapy (ART). The initial response to HBV vaccination also plays a critical role in the sustainability of antibody responses in both HIV-1-infected and uninfected vaccinees. Thus, regular follow-up for antibody titer and a booster dose is warranted to prevent HBV transmission in HIV-1 infected people.https://www.mdpi.com/2076-393X/9/12/1484HBVHBV vaccineanti-HBs antibodiesHIV-1booster doseB cells |
| spellingShingle | Yonas Bekele Jay A. Berzofsky Francesca Chiodi Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals Vaccines HBV HBV vaccine anti-HBs antibodies HIV-1 booster dose B cells |
| title | Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals |
| title_full | Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals |
| title_fullStr | Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals |
| title_full_unstemmed | Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals |
| title_short | Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals |
| title_sort | undetectable anti hbs antibodies need of a booster dose for hiv 1 infected individuals |
| topic | HBV HBV vaccine anti-HBs antibodies HIV-1 booster dose B cells |
| url | https://www.mdpi.com/2076-393X/9/12/1484 |
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