The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes
The aim of the current study was to determine whether the rs17602729 polymorphism in the Adenosine monophosphate deaminase-1 (<i>AMPD1</i>) gene is related to elite athlete performance. A total of 60 elite athletes, aged 18–35, who were split into two groups—31 sprinters/power athletes a...
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MDPI AG
2024-01-01
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| author | Celal Bulgay Veli Ozan Çakır Hasan Hüseyin Kazan Mehmet Ali Ergün Georgian Badicu Luca Paolo Ardigò |
| author_facet | Celal Bulgay Veli Ozan Çakır Hasan Hüseyin Kazan Mehmet Ali Ergün Georgian Badicu Luca Paolo Ardigò |
| author_sort | Celal Bulgay |
| collection | DOAJ |
| description | The aim of the current study was to determine whether the rs17602729 polymorphism in the Adenosine monophosphate deaminase-1 (<i>AMPD1</i>) gene is related to elite athlete performance. A total of 60 elite athletes, aged 18–35, who were split into two groups—31 sprinters/power athletes and 29 endurance athletes—as well as 20 control/sedentary individuals, willingly participated in the study. The performance levels of the athletes, based on their personal bests (PBs), were rated using the World Athletics (WA) score. Whole exome sequencing (WES) was performed on the genomic DNA that was extracted from the subjects’ blood samples. Using linear regression models, the study sought to determine the relationship between the athletes’ PB, sex, and sport type and the rs17602729 polymorphism both within and between the groups. The distribution of the GG, GA, and AA genotypes of the rs17602729 polymorphism differed significantly within and between the groups, according to the data <i>(p</i> < 0.05). Nonetheless, no statistically significant variations were observed in the correlation between the athletes’ PBs and the rs17602729 polymorphism among the groups (<i>p</i> > 0.05). In conclusion, the G allele of the <i>ADMP1</i> rs17602729 polymorphism appears to provide a benefit to sprinters and power athletes. Nonetheless, to confirm this hypothesis, additional research with more participants and a multi-genetic analysis approach is required. |
| first_indexed | 2024-03-08T09:57:53Z |
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| id | doaj.art-7860b92b01d446e59adf0d83041dd8e0 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-08T09:57:53Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-7860b92b01d446e59adf0d83041dd8e02024-01-29T13:45:39ZengMDPI AGApplied Sciences2076-34172024-01-0114289110.3390/app14020891The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field AthletesCelal Bulgay0Veli Ozan Çakır1Hasan Hüseyin Kazan2Mehmet Ali Ergün3Georgian Badicu4Luca Paolo Ardigò5Sports Science Faculty, Bingol University, 12000 Bingol, TürkiyeSports Science Faculty, Gazi University, 06560 Ankara, TürkiyeMedical Genetics Department, Faculty of Medicine, Near East University, 1010–1107 Mersin, TürkiyeDepartment of Medical Genetics, Faculty of Medicine, Gazi University, 06560 Ankara, TürkiyeDepartment of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University of Braşov, 500068 Braşov, RomaniaDepartment of Teacher Education, NLA University College, 0166 Oslo, NorwayThe aim of the current study was to determine whether the rs17602729 polymorphism in the Adenosine monophosphate deaminase-1 (<i>AMPD1</i>) gene is related to elite athlete performance. A total of 60 elite athletes, aged 18–35, who were split into two groups—31 sprinters/power athletes and 29 endurance athletes—as well as 20 control/sedentary individuals, willingly participated in the study. The performance levels of the athletes, based on their personal bests (PBs), were rated using the World Athletics (WA) score. Whole exome sequencing (WES) was performed on the genomic DNA that was extracted from the subjects’ blood samples. Using linear regression models, the study sought to determine the relationship between the athletes’ PB, sex, and sport type and the rs17602729 polymorphism both within and between the groups. The distribution of the GG, GA, and AA genotypes of the rs17602729 polymorphism differed significantly within and between the groups, according to the data <i>(p</i> < 0.05). Nonetheless, no statistically significant variations were observed in the correlation between the athletes’ PBs and the rs17602729 polymorphism among the groups (<i>p</i> > 0.05). In conclusion, the G allele of the <i>ADMP1</i> rs17602729 polymorphism appears to provide a benefit to sprinters and power athletes. Nonetheless, to confirm this hypothesis, additional research with more participants and a multi-genetic analysis approach is required.https://www.mdpi.com/2076-3417/14/2/891<i>AMPD1</i>athleticsendurance athletesrs17602729polymorphismsprinters |
| spellingShingle | Celal Bulgay Veli Ozan Çakır Hasan Hüseyin Kazan Mehmet Ali Ergün Georgian Badicu Luca Paolo Ardigò The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes Applied Sciences <i>AMPD1</i> athletics endurance athletes rs17602729 polymorphism sprinters |
| title | The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes |
| title_full | The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes |
| title_fullStr | The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes |
| title_full_unstemmed | The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes |
| title_short | The <i>AMPD1</i> Gene’s rs17602729 Polymorphism and Athletic Performance in Track and Field Athletes |
| title_sort | i ampd1 i gene s rs17602729 polymorphism and athletic performance in track and field athletes |
| topic | <i>AMPD1</i> athletics endurance athletes rs17602729 polymorphism sprinters |
| url | https://www.mdpi.com/2076-3417/14/2/891 |
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