Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy
Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and specialized autophagic pathways, (i) the chaperon...
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MDPI AG
2022-06-01
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| Series: | Cells |
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| author | Simon Schnebert Maxime Goguet Emilio J. Vélez Alexandra Depincé Florian Beaumatin Amaury Herpin Iban Seiliez |
| author_facet | Simon Schnebert Maxime Goguet Emilio J. Vélez Alexandra Depincé Florian Beaumatin Amaury Herpin Iban Seiliez |
| author_sort | Simon Schnebert |
| collection | DOAJ |
| description | Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and specialized autophagic pathways, (i) the chaperone-mediated autophagy (CMA) and (ii) the endosomal microautophagy (eMI), both rely on the use of the same cytosolic chaperone HSPA8 (also known as HSC70) for targeting specific substrates to the lysosome. However, this is not true for all organisms, and differences exist between species with respect to the coexistence of these two autophagic routes. In this paper, we present an in-depth analysis of the evolutionary history of the main components of CMA and eMI and discuss how the observed discrepancies between species may contribute to improving our knowledge of these two functions and their interplays. |
| first_indexed | 2024-03-10T00:10:08Z |
| format | Article |
| id | doaj.art-78612b56bd9146489d90f78253d92490 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:10:08Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-78612b56bd9146489d90f78253d924902023-11-23T16:01:58ZengMDPI AGCells2073-44092022-06-011112194510.3390/cells11121945Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated AutophagySimon Schnebert0Maxime Goguet1Emilio J. Vélez2Alexandra Depincé3Florian Beaumatin4Amaury Herpin5Iban Seiliez6E2S UPPA, INRAE, NUMEA, Université de Pau et des Pays de l’Adour, 64310 Saint-Pée-sur-Nivelle, FranceE2S UPPA, INRAE, NUMEA, Université de Pau et des Pays de l’Adour, 64310 Saint-Pée-sur-Nivelle, FranceE2S UPPA, INRAE, NUMEA, Université de Pau et des Pays de l’Adour, 64310 Saint-Pée-sur-Nivelle, FranceUR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu, INRAE, F-35042 Rennes, FranceE2S UPPA, INRAE, NUMEA, Université de Pau et des Pays de l’Adour, 64310 Saint-Pée-sur-Nivelle, FranceUR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu, INRAE, F-35042 Rennes, FranceE2S UPPA, INRAE, NUMEA, Université de Pau et des Pays de l’Adour, 64310 Saint-Pée-sur-Nivelle, FranceAutophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and specialized autophagic pathways, (i) the chaperone-mediated autophagy (CMA) and (ii) the endosomal microautophagy (eMI), both rely on the use of the same cytosolic chaperone HSPA8 (also known as HSC70) for targeting specific substrates to the lysosome. However, this is not true for all organisms, and differences exist between species with respect to the coexistence of these two autophagic routes. In this paper, we present an in-depth analysis of the evolutionary history of the main components of CMA and eMI and discuss how the observed discrepancies between species may contribute to improving our knowledge of these two functions and their interplays.https://www.mdpi.com/2073-4409/11/12/1945chaperone-mediated autophagyCMALAMP2AHSC70KFERQendosomal microautophagy |
| spellingShingle | Simon Schnebert Maxime Goguet Emilio J. Vélez Alexandra Depincé Florian Beaumatin Amaury Herpin Iban Seiliez Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy Cells chaperone-mediated autophagy CMA LAMP2A HSC70 KFERQ endosomal microautophagy |
| title | Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy |
| title_full | Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy |
| title_fullStr | Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy |
| title_full_unstemmed | Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy |
| title_short | Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy |
| title_sort | diving into the evolutionary history of hsc70 linked selective autophagy pathways endosomal microautophagy and chaperone mediated autophagy |
| topic | chaperone-mediated autophagy CMA LAMP2A HSC70 KFERQ endosomal microautophagy |
| url | https://www.mdpi.com/2073-4409/11/12/1945 |
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