A unique uterine cervical “teratocarcinosarcoma”: a case report
Abstract Background Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closely resembling TCS have been reported; however, there has been no publish...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-019-0890-5 |
| _version_ | 1819008538628849664 |
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| author | Kozue Ito Mitsutake Yano Aiko Ogasawara Maiko Miwa Eito Kozawa Masanori Yasuda |
| author_facet | Kozue Ito Mitsutake Yano Aiko Ogasawara Maiko Miwa Eito Kozawa Masanori Yasuda |
| author_sort | Kozue Ito |
| collection | DOAJ |
| description | Abstract Background Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closely resembling TCS have been reported; however, there has been no published case of cervical TCS. Herein, we describe a unique case of cervical tumor that had carcinosarcomatous and teratomatous features, resembling a sinonasal TCS. Case presentation A 45-year-old woman presented to our hospital for evaluation of a cervical lesion. The gynecologist found a large polypoid mass, whose biopsy showed glandular components of probable germ cell origin based on the immunohistochemical features. The patient underwent total hysterectomy with bilateral salpingo-oophorectomy. The cervical polypoid mass was found to consist of both epithelial and mesenchymal tissues, including immature glandular structure resembling fetal enteric tubules, neuroepithelial cells, hyaline cartilage, and rhabdomyosarcoma cells. This tumor was diagnosed as TCS of the uterine cervix. Following the surgery, the patient received radiotherapy and has been free of disease for 13 months. Conclusion This is the first case report of cervical TCS. The tumor is thought to be histogenetically less associated with HPV infection, and its teratomatous components with an absence of cytogenetic abnormalities (including isochromosome 12p (i(12p)) suggest a analogous histogenesis compared to pure mature or immature teratoma. |
| first_indexed | 2024-12-21T00:42:04Z |
| format | Article |
| id | doaj.art-7861c9346f1047ddbfaceb7cd9d7dbd2 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-21T00:42:04Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-7861c9346f1047ddbfaceb7cd9d7dbd22022-12-21T19:21:39ZengBMCDiagnostic Pathology1746-15962019-11-011411610.1186/s13000-019-0890-5A unique uterine cervical “teratocarcinosarcoma”: a case reportKozue Ito0Mitsutake Yano1Aiko Ogasawara2Maiko Miwa3Eito Kozawa4Masanori Yasuda5Department of Pathology, Saitama Medical University International Medical CenterDepartment of Pathology, Saitama Medical University International Medical CenterDepartment of Gynecologic Oncology, Saitama Medical University International Medical CenterDepartment of Gynecologic Oncology, Saitama Medical University International Medical CenterDepartment of Diagnostic Radiology, Saitama Medical University HospitalDepartment of Pathology, Saitama Medical University International Medical CenterAbstract Background Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closely resembling TCS have been reported; however, there has been no published case of cervical TCS. Herein, we describe a unique case of cervical tumor that had carcinosarcomatous and teratomatous features, resembling a sinonasal TCS. Case presentation A 45-year-old woman presented to our hospital for evaluation of a cervical lesion. The gynecologist found a large polypoid mass, whose biopsy showed glandular components of probable germ cell origin based on the immunohistochemical features. The patient underwent total hysterectomy with bilateral salpingo-oophorectomy. The cervical polypoid mass was found to consist of both epithelial and mesenchymal tissues, including immature glandular structure resembling fetal enteric tubules, neuroepithelial cells, hyaline cartilage, and rhabdomyosarcoma cells. This tumor was diagnosed as TCS of the uterine cervix. Following the surgery, the patient received radiotherapy and has been free of disease for 13 months. Conclusion This is the first case report of cervical TCS. The tumor is thought to be histogenetically less associated with HPV infection, and its teratomatous components with an absence of cytogenetic abnormalities (including isochromosome 12p (i(12p)) suggest a analogous histogenesis compared to pure mature or immature teratoma.http://link.springer.com/article/10.1186/s13000-019-0890-5Uterine cervixTeratomaCarcinosarcomaTeratocarcinosarcoma |
| spellingShingle | Kozue Ito Mitsutake Yano Aiko Ogasawara Maiko Miwa Eito Kozawa Masanori Yasuda A unique uterine cervical “teratocarcinosarcoma”: a case report Diagnostic Pathology Uterine cervix Teratoma Carcinosarcoma Teratocarcinosarcoma |
| title | A unique uterine cervical “teratocarcinosarcoma”: a case report |
| title_full | A unique uterine cervical “teratocarcinosarcoma”: a case report |
| title_fullStr | A unique uterine cervical “teratocarcinosarcoma”: a case report |
| title_full_unstemmed | A unique uterine cervical “teratocarcinosarcoma”: a case report |
| title_short | A unique uterine cervical “teratocarcinosarcoma”: a case report |
| title_sort | unique uterine cervical teratocarcinosarcoma a case report |
| topic | Uterine cervix Teratoma Carcinosarcoma Teratocarcinosarcoma |
| url | http://link.springer.com/article/10.1186/s13000-019-0890-5 |
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