Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution
Background/Aims: In recent years, one of technical attempts to improve biocompatibility and tolerability of the hemodialysis procedure is the substitution of acetate in dialysis solution with citrate. The aim of our study was to compare two dialysis solutions: traditional bicarbonate dialysis soluti...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2015-01-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | http://www.karger.com/Article/FullText/368478 |
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| author | Roman Šafránek Petr Moučka Jaroslava Vávrová Vladimír Palička Ladislava Pavlíková Sylvie Dusilová Sulková |
| author_facet | Roman Šafránek Petr Moučka Jaroslava Vávrová Vladimír Palička Ladislava Pavlíková Sylvie Dusilová Sulková |
| author_sort | Roman Šafránek |
| collection | DOAJ |
| description | Background/Aims: In recent years, one of technical attempts to improve biocompatibility and tolerability of the hemodialysis procedure is the substitution of acetate in dialysis solution with citrate. The aim of our study was to compare two dialysis solutions: traditional bicarbonate dialysis solution containing acetate (3 mmol/L) (solution A); and (solution C) commercially produced citrate-enriched bicarbonate dialysis solution (0.8 mmol/L citrate). Methods: Patients from a single hemodialysis center (N=126) were included in the study. Both conventional low-flux hemodialysis and on-line hemodiafiltration procedures were studied. Both dialysis solutions contained identical calcium (1.5 mmol/L) and magnesium (0.5 mmol/L) concentrations. Results: Parathyroid hormone (iPTH) concentration decreased during procedures with solution A by 64%. On the contrary, when solution C was used, iPTH concentration increased insignificantly by 4%. For solution A, serum calcium and magnesium increased during procedures in patients with predialysis concentrations lower than 2.33 and 0.76 mmol/L, respectively. In procedures with dialysis solution C these concentrations were significantly lower: 2.19 mmol/L for Ca and 0.68 mmol/L for Mg. Conclusion: Our study clearly shows that the substitution of part of acetate with citrate in dialysis solution significantly influences changes of serum calcium, magnesium and parathyroid hormone concentrations during hemodialysis and hemodiafiltration procedures. |
| first_indexed | 2024-12-12T20:02:23Z |
| format | Article |
| id | doaj.art-7862f48a34dd463a9f0e21a6911b7ba7 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-12T20:02:23Z |
| publishDate | 2015-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-7862f48a34dd463a9f0e21a6911b7ba72022-12-22T00:13:42ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432015-01-01401132110.1159/000368478368478Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis SolutionRoman ŠafránekPetr MoučkaJaroslava VávrováVladimír PaličkaLadislava PavlíkováSylvie Dusilová SulkováBackground/Aims: In recent years, one of technical attempts to improve biocompatibility and tolerability of the hemodialysis procedure is the substitution of acetate in dialysis solution with citrate. The aim of our study was to compare two dialysis solutions: traditional bicarbonate dialysis solution containing acetate (3 mmol/L) (solution A); and (solution C) commercially produced citrate-enriched bicarbonate dialysis solution (0.8 mmol/L citrate). Methods: Patients from a single hemodialysis center (N=126) were included in the study. Both conventional low-flux hemodialysis and on-line hemodiafiltration procedures were studied. Both dialysis solutions contained identical calcium (1.5 mmol/L) and magnesium (0.5 mmol/L) concentrations. Results: Parathyroid hormone (iPTH) concentration decreased during procedures with solution A by 64%. On the contrary, when solution C was used, iPTH concentration increased insignificantly by 4%. For solution A, serum calcium and magnesium increased during procedures in patients with predialysis concentrations lower than 2.33 and 0.76 mmol/L, respectively. In procedures with dialysis solution C these concentrations were significantly lower: 2.19 mmol/L for Ca and 0.68 mmol/L for Mg. Conclusion: Our study clearly shows that the substitution of part of acetate with citrate in dialysis solution significantly influences changes of serum calcium, magnesium and parathyroid hormone concentrations during hemodialysis and hemodiafiltration procedures.http://www.karger.com/Article/FullText/368478CitrateDialysis solutionHemodialysisCalciumMagnesiumParathyroid hormoneHemodiafiltrationAcetate |
| spellingShingle | Roman Šafránek Petr Moučka Jaroslava Vávrová Vladimír Palička Ladislava Pavlíková Sylvie Dusilová Sulková Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution Kidney & Blood Pressure Research Citrate Dialysis solution Hemodialysis Calcium Magnesium Parathyroid hormone Hemodiafiltration Acetate |
| title | Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution |
| title_full | Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution |
| title_fullStr | Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution |
| title_full_unstemmed | Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution |
| title_short | Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution |
| title_sort | changes of serum calcium magnesium and parathyroid hormone induced by hemodialysis with citrate enriched dialysis solution |
| topic | Citrate Dialysis solution Hemodialysis Calcium Magnesium Parathyroid hormone Hemodiafiltration Acetate |
| url | http://www.karger.com/Article/FullText/368478 |
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