IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis

IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis

Summary: Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic stem cells (HSCs), we performed gene expression prof...

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Bibliographic Details
Main Authors: Han J.M.P. Verhagen, Noortje van Gils, Tania Martiañez, Anna van Rhenen, Arjo Rutten, Fedor Denkers, David C. de Leeuw, Marjon A. Smit, Mei-Ling Tsui, Louise L.E. de Vos Klootwijk, Renee X. Menezes, Meyram Çil, Margaretha G.M. Roemer, Eline Vermue, Stan Heukelom, Sonja Zweegman, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Linda Smit
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318382

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http://www.sciencedirect.com/science/article/pii/S2211124718318382

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