Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target.

Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target.

Tuberculosis (TB) is one of the leading infectious diseases of global concern, and one quarter of the world's population are TB carriers. Biotin metabolism appears to be an attractive anti-TB drug target. However, the first-stage of mycobacterial biotin synthesis is fragmentarily understood. He...

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Bibliographic Details
Main Authors: Yongchang Xu, Jie Yang, Weihui Li, Shuaijie Song, Yu Shi, Lihan Wu, Jingdu Sun, Mengyun Hou, Jinzi Wang, Xu Jia, Huimin Zhang, Man Huang, Ting Lu, Jianhua Gan, Youjun Feng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010615

Internet

https://doi.org/10.1371/journal.ppat.1010615

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