Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal
Abstract Background Flavonoids are important plant secondary metabolites (PSMs) that have been widely used for their health-promoting effects. However, little is known about overall flavonoid metabolism and the interactive effects between flavonoids and the gut microbiota. The flavonoid-rich bamboo...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Microbiome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40168-021-01142-6 |
| _version_ | 1819153864564146176 |
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| author | Le Wang Guangping Huang Rong Hou Dunwu Qi Qi Wu Yonggang Nie Zhenqiang Zuo Rui Ma Wenliang Zhou Yingjie Ma Yibo Hu Zhisong Yang Li Yan Fuwen Wei |
| author_facet | Le Wang Guangping Huang Rong Hou Dunwu Qi Qi Wu Yonggang Nie Zhenqiang Zuo Rui Ma Wenliang Zhou Yingjie Ma Yibo Hu Zhisong Yang Li Yan Fuwen Wei |
| author_sort | Le Wang |
| collection | DOAJ |
| description | Abstract Background Flavonoids are important plant secondary metabolites (PSMs) that have been widely used for their health-promoting effects. However, little is known about overall flavonoid metabolism and the interactive effects between flavonoids and the gut microbiota. The flavonoid-rich bamboo and the giant panda provide an ideal system to bridge this gap. Results Here, integrating metabolomic and metagenomic approaches, and in vitro culture experiment, we identified 97 flavonoids in bamboo and most of them have not been identified previously; the utilization of more than 70% flavonoid monomers was attributed to gut microbiota; the variation of flavonoid in bamboo leaves and shoots shaped the seasonal microbial fluctuation. The greater the flavonoid content in the diet was, the lower microbial diversity and virulence factor, but the more cellulose-degrading species. Conclusions Our study shows an unprecedented landscape of beneficial PSMs in a non-model mammal and reveals that PSMs remodel the gut microbiota conferring host adaptation to diet transition in an ecological context, providing a novel insight into host-microbe interaction. Video abstract |
| first_indexed | 2024-12-22T15:11:58Z |
| format | Article |
| id | doaj.art-7864f8b1f0864136a12cc35b0b09e35c |
| institution | Directory Open Access Journal |
| issn | 2049-2618 |
| language | English |
| last_indexed | 2024-12-22T15:11:58Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj.art-7864f8b1f0864136a12cc35b0b09e35c2022-12-21T18:21:51ZengBMCMicrobiome2049-26182021-09-019111510.1186/s40168-021-01142-6Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammalLe Wang0Guangping Huang1Rong Hou2Dunwu Qi3Qi Wu4Yonggang Nie5Zhenqiang Zuo6Rui Ma7Wenliang Zhou8Yingjie Ma9Yibo Hu10Zhisong Yang11Li Yan12Fuwen Wei13Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesChengdu Research Base of Giant Panda BreedingChengdu Research Base of Giant Panda BreedingKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)Chengdu Research Base of Giant Panda BreedingKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesSichuan Academy of Giant PandaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of SciencesAbstract Background Flavonoids are important plant secondary metabolites (PSMs) that have been widely used for their health-promoting effects. However, little is known about overall flavonoid metabolism and the interactive effects between flavonoids and the gut microbiota. The flavonoid-rich bamboo and the giant panda provide an ideal system to bridge this gap. Results Here, integrating metabolomic and metagenomic approaches, and in vitro culture experiment, we identified 97 flavonoids in bamboo and most of them have not been identified previously; the utilization of more than 70% flavonoid monomers was attributed to gut microbiota; the variation of flavonoid in bamboo leaves and shoots shaped the seasonal microbial fluctuation. The greater the flavonoid content in the diet was, the lower microbial diversity and virulence factor, but the more cellulose-degrading species. Conclusions Our study shows an unprecedented landscape of beneficial PSMs in a non-model mammal and reveals that PSMs remodel the gut microbiota conferring host adaptation to diet transition in an ecological context, providing a novel insight into host-microbe interaction. Video abstracthttps://doi.org/10.1186/s40168-021-01142-6PSMsFlavonoidsGiant pandasMetabolomicsMetagenomics |
| spellingShingle | Le Wang Guangping Huang Rong Hou Dunwu Qi Qi Wu Yonggang Nie Zhenqiang Zuo Rui Ma Wenliang Zhou Yingjie Ma Yibo Hu Zhisong Yang Li Yan Fuwen Wei Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal Microbiome PSMs Flavonoids Giant pandas Metabolomics Metagenomics |
| title | Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal |
| title_full | Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal |
| title_fullStr | Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal |
| title_full_unstemmed | Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal |
| title_short | Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal |
| title_sort | multi omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non model mammal |
| topic | PSMs Flavonoids Giant pandas Metabolomics Metagenomics |
| url | https://doi.org/10.1186/s40168-021-01142-6 |
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