Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes
Background: Chorioamnionitis complicates about 1–5% of deliveries at term and causes about one-third of stillbirths. CXC-chemokine receptor 1 (CXCR1) binds IL-8 with high affinity and regulates neutrophil recruitment. We aimed to determine the immunoexpression of CXCR1 in placentas with chorioamnion...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/4/882 |
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| author | Yin Ping Wong Noorhafizah Wagiman Jonathan Wei De Tan Barizah Syahirah Hanim Muhammad Syamil Hilman Rashidan Kai Mun Fong Naufal Naqib Norhazli Yashini Qrisha Raja Norazah Raja Alam Shah Muaatamarulain Mustangin Haliza Zakaria Siew Xian Chin Geok Chin Tan |
| author_facet | Yin Ping Wong Noorhafizah Wagiman Jonathan Wei De Tan Barizah Syahirah Hanim Muhammad Syamil Hilman Rashidan Kai Mun Fong Naufal Naqib Norhazli Yashini Qrisha Raja Norazah Raja Alam Shah Muaatamarulain Mustangin Haliza Zakaria Siew Xian Chin Geok Chin Tan |
| author_sort | Yin Ping Wong |
| collection | DOAJ |
| description | Background: Chorioamnionitis complicates about 1–5% of deliveries at term and causes about one-third of stillbirths. CXC-chemokine receptor 1 (CXCR1) binds IL-8 with high affinity and regulates neutrophil recruitment. We aimed to determine the immunoexpression of CXCR1 in placentas with chorioamnionitis, and its association with adverse perinatal outcomes. Methods: A total of 101 cases of chorioamnionitis and 32 cases of non-chorioamnionitis were recruited over a period of 2 years. CXCR1 immunohistochemistry was performed, and its immunoexpression in placentas was evaluated. The adverse perinatal outcomes included intrauterine death, poor APGAR score, early neonatal death, and respiratory complications. Results: Seventeen cases (17/101, 16.8%) with chorioamnionitis presented as preterm deliveries. Lung complications were more common in mothers who were >35 years (<i>p</i> = 0.003) and with a higher stage in the foetal inflammatory response (<i>p</i> = 0.03). Notably, 24 cases (23.8%) of histological chorioamnionitis were not detected clinically. Interestingly, the loss of CXCR1 immunoexpression in the umbilical cord endothelial cells (UCECs) was significantly associated with foetal death (<i>p</i> = 0.009). Conclusion: The loss of CXCR1 expression in UCECs was significantly associated with an increased risk of adverse perinatal outcomes and could be used as a biomarker to predict adverse perinatal outcomes in chorioamnionitis. Further study is warranted to study the pathophysiology involved in the failure of CXCR1 expression in these cells. |
| first_indexed | 2024-03-09T10:57:19Z |
| format | Article |
| id | doaj.art-7868250630c74bb38a7526a8b9e78c60 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T10:57:19Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7868250630c74bb38a7526a8b9e78c602023-12-01T01:32:24ZengMDPI AGDiagnostics2075-44182022-04-0112488210.3390/diagnostics12040882Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal OutcomesYin Ping Wong0Noorhafizah Wagiman1Jonathan Wei De Tan2Barizah Syahirah Hanim3Muhammad Syamil Hilman Rashidan4Kai Mun Fong5Naufal Naqib Norhazli6Yashini Qrisha7Raja Norazah Raja Alam Shah8Muaatamarulain Mustangin9Haliza Zakaria10Siew Xian Chin11Geok Chin Tan12Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaASASIpintar Programme, Pusat Genius@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaASASIpintar Programme, Pusat Genius@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaASASIpintar Programme, Pusat Genius@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaASASIpintar Programme, Pusat Genius@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaASASIpintar Programme, Pusat Genius@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaDepartment of Pathology, Hospital Sultanah Aminah, Johor Bahru 80100, MalaysiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaASASIpintar Programme, Pusat Genius@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi 43600, MalaysiaDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaBackground: Chorioamnionitis complicates about 1–5% of deliveries at term and causes about one-third of stillbirths. CXC-chemokine receptor 1 (CXCR1) binds IL-8 with high affinity and regulates neutrophil recruitment. We aimed to determine the immunoexpression of CXCR1 in placentas with chorioamnionitis, and its association with adverse perinatal outcomes. Methods: A total of 101 cases of chorioamnionitis and 32 cases of non-chorioamnionitis were recruited over a period of 2 years. CXCR1 immunohistochemistry was performed, and its immunoexpression in placentas was evaluated. The adverse perinatal outcomes included intrauterine death, poor APGAR score, early neonatal death, and respiratory complications. Results: Seventeen cases (17/101, 16.8%) with chorioamnionitis presented as preterm deliveries. Lung complications were more common in mothers who were >35 years (<i>p</i> = 0.003) and with a higher stage in the foetal inflammatory response (<i>p</i> = 0.03). Notably, 24 cases (23.8%) of histological chorioamnionitis were not detected clinically. Interestingly, the loss of CXCR1 immunoexpression in the umbilical cord endothelial cells (UCECs) was significantly associated with foetal death (<i>p</i> = 0.009). Conclusion: The loss of CXCR1 expression in UCECs was significantly associated with an increased risk of adverse perinatal outcomes and could be used as a biomarker to predict adverse perinatal outcomes in chorioamnionitis. Further study is warranted to study the pathophysiology involved in the failure of CXCR1 expression in these cells.https://www.mdpi.com/2075-4418/12/4/882chorioamnionitisCXCR1interleukin-8perinatalplacenta |
| spellingShingle | Yin Ping Wong Noorhafizah Wagiman Jonathan Wei De Tan Barizah Syahirah Hanim Muhammad Syamil Hilman Rashidan Kai Mun Fong Naufal Naqib Norhazli Yashini Qrisha Raja Norazah Raja Alam Shah Muaatamarulain Mustangin Haliza Zakaria Siew Xian Chin Geok Chin Tan Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes Diagnostics chorioamnionitis CXCR1 interleukin-8 perinatal placenta |
| title | Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes |
| title_full | Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes |
| title_fullStr | Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes |
| title_full_unstemmed | Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes |
| title_short | Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes |
| title_sort | loss of cxc chemokine receptor 1 expression in chorioamnionitis is associated with adverse perinatal outcomes |
| topic | chorioamnionitis CXCR1 interleukin-8 perinatal placenta |
| url | https://www.mdpi.com/2075-4418/12/4/882 |
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