Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods
The examination of a drug in water and other aqueous systems gives insight into the chemistry of biological systems. This work aims to study the physico-chemical properties of chlorpheniramine maleate (drug) in water and aq-MeOH/EG (mono/dihydric alcohols) systems at different temperatures by using...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2022-09-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/72225 |
| _version_ | 1798031140482711552 |
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| author | Zainab Khan Summyia Masood Nighat Shafi Rafia Azmat Salman Khurshid Samreen Begum |
| author_facet | Zainab Khan Summyia Masood Nighat Shafi Rafia Azmat Salman Khurshid Samreen Begum |
| author_sort | Zainab Khan |
| collection | DOAJ |
| description | The examination of a drug in water and other aqueous systems gives insight into the chemistry of biological systems. This work aims to study the physico-chemical properties of chlorpheniramine maleate (drug) in water and aq-MeOH/EG (mono/dihydric alcohols) systems at different temperatures by using different techniques. Densities and viscosities of chlorpheniramine maleate in water and also in MeOH/EG aqueous solutions have been measured over a temperature range of 298.15 to 318.15 K. Number of several parameters, i.e., apparent molar volume (ϕv), partial molar volume (ϕvo), Hepler’s constant (∂CΡ/∂Ρ)T, Falkenhagen coefficient (A), and Jones-Dole coefficient (B) have been calculated by using experimentally measured density and viscosity values. The mentioned calculated parameters were found to be valuable in perceiving drug-drug and drug-solvent interactions. Moreover, one of the liquid chromatographic techniques such as RP-HPLC has also been performed, and the outcomes supported the conclusion procured from the volumetric and viscometric studies. Drug interactions help to understand their behavior in different solvent systems during drug development. |
| first_indexed | 2024-04-11T19:52:47Z |
| format | Article |
| id | doaj.art-7868ab95f9fb4ab38724cbf92b821198 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-04-11T19:52:47Z |
| publishDate | 2022-09-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-7868ab95f9fb4ab38724cbf92b8211982022-12-22T04:06:16ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782022-09-012251218123210.22146/ijc.7222532425Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC MethodsZainab Khan0Summyia Masood1Nighat Shafi2Rafia Azmat3Salman Khurshid4Samreen Begum5Department of Chemistry, University of Karachi, Karachi-75270, PakistanDepartment of Chemistry, University of Karachi, Karachi-75270, PakistanDepartment of Chemistry, University of Karachi, Karachi-75270, PakistanDepartment of Chemistry, University of Karachi, Karachi-75270, PakistanSouthern-zone Agriculture Research Center, (PARC) Karachi University Campus, Karachi-75270, PakistanDepartment of Chemistry, University of Karachi, Karachi-75270, PakistanThe examination of a drug in water and other aqueous systems gives insight into the chemistry of biological systems. This work aims to study the physico-chemical properties of chlorpheniramine maleate (drug) in water and aq-MeOH/EG (mono/dihydric alcohols) systems at different temperatures by using different techniques. Densities and viscosities of chlorpheniramine maleate in water and also in MeOH/EG aqueous solutions have been measured over a temperature range of 298.15 to 318.15 K. Number of several parameters, i.e., apparent molar volume (ϕv), partial molar volume (ϕvo), Hepler’s constant (∂CΡ/∂Ρ)T, Falkenhagen coefficient (A), and Jones-Dole coefficient (B) have been calculated by using experimentally measured density and viscosity values. The mentioned calculated parameters were found to be valuable in perceiving drug-drug and drug-solvent interactions. Moreover, one of the liquid chromatographic techniques such as RP-HPLC has also been performed, and the outcomes supported the conclusion procured from the volumetric and viscometric studies. Drug interactions help to understand their behavior in different solvent systems during drug development.https://jurnal.ugm.ac.id/ijc/article/view/72225apparent molar volumerp-hplcdrug-solvent interactionschlorpheniramine maleate |
| spellingShingle | Zainab Khan Summyia Masood Nighat Shafi Rafia Azmat Salman Khurshid Samreen Begum Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods Indonesian Journal of Chemistry apparent molar volume rp-hplc drug-solvent interactions chlorpheniramine maleate |
| title | Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods |
| title_full | Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods |
| title_fullStr | Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods |
| title_full_unstemmed | Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods |
| title_short | Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods |
| title_sort | interaction studies of chlorpheniramine maleate in mono and dihydric alcohols by density viscosity and hplc methods |
| topic | apparent molar volume rp-hplc drug-solvent interactions chlorpheniramine maleate |
| url | https://jurnal.ugm.ac.id/ijc/article/view/72225 |
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