Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10194-0 |
| _version_ | 1818858743600775168 |
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| author | Hyeongsun Moon Jerry Zhu Leanne R. Donahue Eunju Choi Andrew C. White |
| author_facet | Hyeongsun Moon Jerry Zhu Leanne R. Donahue Eunju Choi Andrew C. White |
| author_sort | Hyeongsun Moon |
| collection | DOAJ |
| description | Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population. |
| first_indexed | 2024-12-19T09:01:08Z |
| format | Article |
| id | doaj.art-7869f89b2952464bb4c94fa9d186093f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T09:01:08Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7869f89b2952464bb4c94fa9d186093f2022-12-21T20:28:29ZengNature PortfolioNature Communications2041-17232019-05-0110111010.1038/s41467-019-10194-0Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stressHyeongsun Moon0Jerry Zhu1Leanne R. Donahue2Eunju Choi3Andrew C. White4Department of Biomedical Sciences, Cornell UniversityDepartment of Biomedical Sciences, Cornell UniversityDepartment of Biomedical Sciences, Cornell UniversityDepartment of Pathology, Microbiology and Immunology, University of California DavisDepartment of Biomedical Sciences, Cornell UniversityCellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.https://doi.org/10.1038/s41467-019-10194-0 |
| spellingShingle | Hyeongsun Moon Jerry Zhu Leanne R. Donahue Eunju Choi Andrew C. White Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress Nature Communications |
| title | Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress |
| title_full | Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress |
| title_fullStr | Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress |
| title_full_unstemmed | Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress |
| title_short | Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress |
| title_sort | krt5 krt15 foregut basal progenitors give rise to cyclooxygenase 2 dependent tumours in response to gastric acid stress |
| url | https://doi.org/10.1038/s41467-019-10194-0 |
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