Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia
A stem ethanol extract of Bauhinia strychnifolia and its compounds were investigated for their anti-HIV-1 integrase (IN) and anti-allergic activities. From bioassay-guided isolation, five compounds including quercetin (1), 3,5,7,3',5' pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside (2), 3,...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2013-12-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://rdo.psu.ac.th/sjstweb/journal/35-6/35-6-6.pdf |
| _version_ | 1811203974726942720 |
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| author | Kingkan Bunluepuech Chatchai Wattanapiromsakul Fameera Madaka Supinya Tewtrakul |
| author_facet | Kingkan Bunluepuech Chatchai Wattanapiromsakul Fameera Madaka Supinya Tewtrakul |
| author_sort | Kingkan Bunluepuech |
| collection | DOAJ |
| description | A stem ethanol extract of Bauhinia strychnifolia and its compounds were investigated for their anti-HIV-1 integrase (IN) and anti-allergic activities. From bioassay-guided isolation, five compounds including quercetin (1), 3,5,7,3',5' pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside (2), 3,5,7-trihydroxychromone-3-α-L-rhamnopyranoside (3) and a mixture of β-sitosterol (4) and stigmasterol (5) were isolated. Of the tested samples, compound 1 (quercetin) showed the highest activity against HIV-1 IN with an IC50 value of 15.2 µM, followed by 3 (3,5,7-trihydroxychromone-3-α-L-rhamnopyranoside), 4+5 (mixture of β-sitosterol and stigmasterol) and 2 (3,5,7,3',5'-pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside) with % inhibition of 28.2, 26.2 and 6.7 at 100 µM, respectively. With regard to anti-allergic activity, quercetin (1) possessed the highest anti-allergic activity with an IC50 of 8.1 µM, followed by 3 (3,5,7-trihydroxychromone-3-α-L-rhamnopyranoside) and 4+5 (mixture of β-sitosterol and stigmasterol) with IC50 values of 52.1 and 77.5 µM, respectively. Whereas compound 2 (3,5,7,3',5'-pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside) was inactive. The present study is the first report of chemical constituents and biological activities of Bauhinia strychnifolia. |
| first_indexed | 2024-04-12T03:04:55Z |
| format | Article |
| id | doaj.art-786a91e53d47451daa7a75d3408262ef |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-12T03:04:55Z |
| publishDate | 2013-12-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-786a91e53d47451daa7a75d3408262ef2022-12-22T03:50:32ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952013-12-01356659664Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifoliaKingkan Bunluepuech0Chatchai Wattanapiromsakul1Fameera Madaka2Supinya Tewtrakul3Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.A stem ethanol extract of Bauhinia strychnifolia and its compounds were investigated for their anti-HIV-1 integrase (IN) and anti-allergic activities. From bioassay-guided isolation, five compounds including quercetin (1), 3,5,7,3',5' pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside (2), 3,5,7-trihydroxychromone-3-α-L-rhamnopyranoside (3) and a mixture of β-sitosterol (4) and stigmasterol (5) were isolated. Of the tested samples, compound 1 (quercetin) showed the highest activity against HIV-1 IN with an IC50 value of 15.2 µM, followed by 3 (3,5,7-trihydroxychromone-3-α-L-rhamnopyranoside), 4+5 (mixture of β-sitosterol and stigmasterol) and 2 (3,5,7,3',5'-pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside) with % inhibition of 28.2, 26.2 and 6.7 at 100 µM, respectively. With regard to anti-allergic activity, quercetin (1) possessed the highest anti-allergic activity with an IC50 of 8.1 µM, followed by 3 (3,5,7-trihydroxychromone-3-α-L-rhamnopyranoside) and 4+5 (mixture of β-sitosterol and stigmasterol) with IC50 values of 52.1 and 77.5 µM, respectively. Whereas compound 2 (3,5,7,3',5'-pentahydroxyflavanonol-3-O-α-L-rhamnopyranoside) was inactive. The present study is the first report of chemical constituents and biological activities of Bauhinia strychnifolia.http://rdo.psu.ac.th/sjstweb/journal/35-6/35-6-6.pdfanti-HIV-1 integraseanti-allergyBauhinia strychnifoliaFabaceae |
| spellingShingle | Kingkan Bunluepuech Chatchai Wattanapiromsakul Fameera Madaka Supinya Tewtrakul Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia Songklanakarin Journal of Science and Technology (SJST) anti-HIV-1 integrase anti-allergy Bauhinia strychnifolia Fabaceae |
| title | Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia |
| title_full | Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia |
| title_fullStr | Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia |
| title_full_unstemmed | Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia |
| title_short | Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia |
| title_sort | anti hiv 1 integrase and anti allergic activities of bauhinia strychnifolia |
| topic | anti-HIV-1 integrase anti-allergy Bauhinia strychnifolia Fabaceae |
| url | http://rdo.psu.ac.th/sjstweb/journal/35-6/35-6-6.pdf |
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