Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry
Abstract Background Little is known about the association between juvenile idiopathic arthritis (JIA) and autoimmune thyroid disease (AITD) and therefore there are no indications for AITD screening in this population, which is possible using standard blood tests. The objective of this study is to de...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00802-1 |
| _version_ | 1797865327138177024 |
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| author | Joeri W. van Straalen Laurie Baas Gabriella Giancane Lyudmila Grebenkina Jurgen Brunner Gabriel Vega-Cornejo Vyacheslav G. Chasnyk Liora Harel Simone Appenzeller Elisabeth Gervais Sytze de Roock Nico M. Wulffraat Nicolino Ruperto Joost F. Swart for the Paediatric Rheumatology International Trials Organisation (PRINTO) |
| author_facet | Joeri W. van Straalen Laurie Baas Gabriella Giancane Lyudmila Grebenkina Jurgen Brunner Gabriel Vega-Cornejo Vyacheslav G. Chasnyk Liora Harel Simone Appenzeller Elisabeth Gervais Sytze de Roock Nico M. Wulffraat Nicolino Ruperto Joost F. Swart for the Paediatric Rheumatology International Trials Organisation (PRINTO) |
| author_sort | Joeri W. van Straalen |
| collection | DOAJ |
| description | Abstract Background Little is known about the association between juvenile idiopathic arthritis (JIA) and autoimmune thyroid disease (AITD) and therefore there are no indications for AITD screening in this population, which is possible using standard blood tests. The objective of this study is to determine the prevalence and predictors of symptomatic AITD in JIA patients from the international Pharmachild registry. Methods Occurrence of AITD was determined from adverse event forms and comorbidity reports. Associated factors and independent predictors for AITD were determined using univariable and multivariable logistic regression analyses. Results The prevalence of AITD after a median observation period of 5.5 years was 1.1% (96/8965 patients). Patients who developed AITD were more often female (83.3% vs. 68.0%), RF positive (10.0% vs. 4.3%) and ANA positive (55.7% vs. 41.5%) than patients who did not. AITD patients were furthermore older at JIA onset (median 7.8 years vs. 5.3 years) and had more often polyarthritis (40.6% vs. 30.4%) and a family history of AITD (27.5% vs. 4.8%) compared to non-AITD patients. A family history of AITD (OR = 6.8, 95% CI: 4.1 – 11.1), female sex (OR = 2.2, 95% CI: 1.3 – 4.3), ANA positivity (OR = 2.0, 95% CI: 1.3 – 3.2) and older age at JIA onset (OR = 1.1, 95% CI: 1.1 – 1.2) were independent predictors of AITD on multivariable analysis. Based on our data, 16 female ANA positive JIA patients with a family history of AITD would have to be screened during ±5.5 years using standard blood tests to detect one case of AITD. Conclusions This is the first study to report independent predictor variables for symptomatic AITD in JIA. Female ANA positive JIA patients with positive family history are at increased risk of developing AITD and thus might benefit from yearly serological screening. |
| first_indexed | 2024-04-09T23:06:17Z |
| format | Article |
| id | doaj.art-786b046087db4ce690f68e94bc5ffa4e |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-04-09T23:06:17Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-786b046087db4ce690f68e94bc5ffa4e2023-03-22T10:40:41ZengBMCPediatric Rheumatology Online Journal1546-00962023-02-012111910.1186/s12969-023-00802-1Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registryJoeri W. van Straalen0Laurie Baas1Gabriella Giancane2Lyudmila Grebenkina3Jurgen Brunner4Gabriel Vega-Cornejo5Vyacheslav G. Chasnyk6Liora Harel7Simone Appenzeller8Elisabeth Gervais9Sytze de Roock10Nico M. Wulffraat11Nicolino Ruperto12Joost F. Swart13for the Paediatric Rheumatology International Trials Organisation (PRINTO)Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital, University Medical Center UtrechtDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital, University Medical Center UtrechtClinica Pediatrica e Reumatologia, IRCCS Istituto Giannina GasliniPediatric Department, Togliatti City Clinical Hospital №5Pediatric Rheumatology, Department of Pediatrics, Medical University InnsbruckClínica Pediátrica de Reumatología y Enfermedades Autoinmunes (CREA), Hospital México AmericanoDepartment of Hospital Pediatrics, Saint Petersburg State Pediatric Medical UniversityPediatric Rheumatology Unit, Schneider Children’s Medical CenterDepartment of Orthopedics, Rheumatology and Traumatology, School of Medical Science, University of CampinasRheumatology, Centre Hospitalier Universitaire (CHU) de PoitiersDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital, University Medical Center UtrechtDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital, University Medical Center UtrechtUOSID Centro trial, IRCCS Istituto Giannina GasliniDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital, University Medical Center UtrechtAbstract Background Little is known about the association between juvenile idiopathic arthritis (JIA) and autoimmune thyroid disease (AITD) and therefore there are no indications for AITD screening in this population, which is possible using standard blood tests. The objective of this study is to determine the prevalence and predictors of symptomatic AITD in JIA patients from the international Pharmachild registry. Methods Occurrence of AITD was determined from adverse event forms and comorbidity reports. Associated factors and independent predictors for AITD were determined using univariable and multivariable logistic regression analyses. Results The prevalence of AITD after a median observation period of 5.5 years was 1.1% (96/8965 patients). Patients who developed AITD were more often female (83.3% vs. 68.0%), RF positive (10.0% vs. 4.3%) and ANA positive (55.7% vs. 41.5%) than patients who did not. AITD patients were furthermore older at JIA onset (median 7.8 years vs. 5.3 years) and had more often polyarthritis (40.6% vs. 30.4%) and a family history of AITD (27.5% vs. 4.8%) compared to non-AITD patients. A family history of AITD (OR = 6.8, 95% CI: 4.1 – 11.1), female sex (OR = 2.2, 95% CI: 1.3 – 4.3), ANA positivity (OR = 2.0, 95% CI: 1.3 – 3.2) and older age at JIA onset (OR = 1.1, 95% CI: 1.1 – 1.2) were independent predictors of AITD on multivariable analysis. Based on our data, 16 female ANA positive JIA patients with a family history of AITD would have to be screened during ±5.5 years using standard blood tests to detect one case of AITD. Conclusions This is the first study to report independent predictor variables for symptomatic AITD in JIA. Female ANA positive JIA patients with positive family history are at increased risk of developing AITD and thus might benefit from yearly serological screening.https://doi.org/10.1186/s12969-023-00802-1Juvenile idiopathic arthritisAutoimmune thyroid diseaseHashimoto’s diseaseGraves’ diseaseScreeningEpidemiology |
| spellingShingle | Joeri W. van Straalen Laurie Baas Gabriella Giancane Lyudmila Grebenkina Jurgen Brunner Gabriel Vega-Cornejo Vyacheslav G. Chasnyk Liora Harel Simone Appenzeller Elisabeth Gervais Sytze de Roock Nico M. Wulffraat Nicolino Ruperto Joost F. Swart for the Paediatric Rheumatology International Trials Organisation (PRINTO) Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry Pediatric Rheumatology Online Journal Juvenile idiopathic arthritis Autoimmune thyroid disease Hashimoto’s disease Graves’ disease Screening Epidemiology |
| title | Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry |
| title_full | Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry |
| title_fullStr | Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry |
| title_full_unstemmed | Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry |
| title_short | Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry |
| title_sort | juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening analysis of the international pharmachild registry |
| topic | Juvenile idiopathic arthritis Autoimmune thyroid disease Hashimoto’s disease Graves’ disease Screening Epidemiology |
| url | https://doi.org/10.1186/s12969-023-00802-1 |
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