Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required...

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Bibliographic Details
Main Authors: Shawn T. Beug, Robert G. Korneluk, Eric C. LaCasse
Format: Article
Language:English
Published: Taylor & Francis Group 2019-07-01
Series:Molecular & Cellular Oncology
Subjects:
ciap1
ciap2
inhibitor of apoptosis
iap antagonist
sp3
specificity protein 3
smac mimetic
ripk1
rnai
cancer
inflammation
mda-mb-231
Online Access:http://dx.doi.org/10.1080/23723556.2019.1607456
Description
Summary:A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions.
ISSN:2372-3556

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