Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1607456 |
| _version_ | 1797677150639226880 |
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| author | Shawn T. Beug Robert G. Korneluk Eric C. LaCasse |
| author_facet | Shawn T. Beug Robert G. Korneluk Eric C. LaCasse |
| author_sort | Shawn T. Beug |
| collection | DOAJ |
| description | A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions. |
| first_indexed | 2024-03-11T22:40:48Z |
| format | Article |
| id | doaj.art-786c185c4b1746e197bb7199ee8e9d32 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:48Z |
| publishDate | 2019-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-786c185c4b1746e197bb7199ee8e9d322023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-07-016410.1080/23723556.2019.16074561607456Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cellsShawn T. Beug0Robert G. Korneluk1Eric C. LaCasse2Children’s Hospital of Eastern Ontario Research InstituteChildren’s Hospital of Eastern Ontario Research InstituteChildren’s Hospital of Eastern Ontario Research InstituteA genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions.http://dx.doi.org/10.1080/23723556.2019.1607456ciap1ciap2inhibitor of apoptosisiap antagonistsp3specificity protein 3smac mimeticripk1rnaicancerinflammationmda-mb-231 |
| spellingShingle | Shawn T. Beug Robert G. Korneluk Eric C. LaCasse Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells Molecular & Cellular Oncology ciap1 ciap2 inhibitor of apoptosis iap antagonist sp3 specificity protein 3 smac mimetic ripk1 rnai cancer inflammation mda-mb-231 |
| title | Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells |
| title_full | Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells |
| title_fullStr | Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells |
| title_full_unstemmed | Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells |
| title_short | Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells |
| title_sort | sp3 cificity of tnf α expression promotes the smac mimetic mediated killing of cancer cells |
| topic | ciap1 ciap2 inhibitor of apoptosis iap antagonist sp3 specificity protein 3 smac mimetic ripk1 rnai cancer inflammation mda-mb-231 |
| url | http://dx.doi.org/10.1080/23723556.2019.1607456 |
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