Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required...
Main Authors: | Shawn T. Beug, Robert G. Korneluk, Eric C. LaCasse |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2019-07-01
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Series: | Molecular & Cellular Oncology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/23723556.2019.1607456 |
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