Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study.
AIM:The role of interleukin 17A (IL-17A) in the inflammatory process has caused interest in the potential significance of IL-17A as a biomarker for coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-17A gene polymorphisms as susceptibility markers for CAD in t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4304820?pdf=render |
| _version_ | 1818318511201583104 |
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| author | Gilberto Vargas-Alarcón Javier Angeles-Martínez Teresa Villarreal-Molina Edith Alvarez-León Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña Julian Ramírez-Bello Nonanzit Pérez-Hernández Juan Gabriel Juárez-Rojas José Manuel Rodríguez-Pérez José Manuel Fragoso Carlos Posadas-Romero |
| author_facet | Gilberto Vargas-Alarcón Javier Angeles-Martínez Teresa Villarreal-Molina Edith Alvarez-León Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña Julian Ramírez-Bello Nonanzit Pérez-Hernández Juan Gabriel Juárez-Rojas José Manuel Rodríguez-Pérez José Manuel Fragoso Carlos Posadas-Romero |
| author_sort | Gilberto Vargas-Alarcón |
| collection | DOAJ |
| description | AIM:The role of interleukin 17A (IL-17A) in the inflammatory process has caused interest in the potential significance of IL-17A as a biomarker for coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-17A gene polymorphisms as susceptibility markers for CAD in the Mexican population. METHODS:Four IL-17A gene polymorphisms (rs8193036, rs3819024, rs2275913 and rs8193037) were genotyped by 5' exonuclease TaqMan assays in a group of 900 patients with premature CAD and 667 healthy controls (with negative calcium score by computed tomography), seeking associations with CAD and other metabolic and cardiovascular risk factors using logistic regression analyses. RESULTS:No single IL-17A polymorphism was associated with premature CAD, however two haplotypes (CAGG and TAGA) were significantly associated with increased risk of premature CAD (OR = 1.35, 95% CI: 1.00-1.84, P = 0.018 and OR = 2.09, 95% CI: 1.16-3.76, P = 0.003, respectively). Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment. CONCLUSION:The results suggest that IL-17A haplotypes are involved in the risk of developing premature CAD and some IL-17A polymorphisms are associated with cardiovascular risk factors in Mexican individuals with premature CAD. |
| first_indexed | 2024-12-13T09:54:23Z |
| format | Article |
| id | doaj.art-786cb3664b2447ec862cca4be9c5e176 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:54:23Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-786cb3664b2447ec862cca4be9c5e1762022-12-21T23:51:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01101e011494310.1371/journal.pone.0114943Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study.Gilberto Vargas-AlarcónJavier Angeles-MartínezTeresa Villarreal-MolinaEdith Alvarez-LeónRosalinda Posadas-SánchezGuillermo Cardoso-SaldañaJulian Ramírez-BelloNonanzit Pérez-HernándezJuan Gabriel Juárez-RojasJosé Manuel Rodríguez-PérezJosé Manuel FragosoCarlos Posadas-RomeroAIM:The role of interleukin 17A (IL-17A) in the inflammatory process has caused interest in the potential significance of IL-17A as a biomarker for coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-17A gene polymorphisms as susceptibility markers for CAD in the Mexican population. METHODS:Four IL-17A gene polymorphisms (rs8193036, rs3819024, rs2275913 and rs8193037) were genotyped by 5' exonuclease TaqMan assays in a group of 900 patients with premature CAD and 667 healthy controls (with negative calcium score by computed tomography), seeking associations with CAD and other metabolic and cardiovascular risk factors using logistic regression analyses. RESULTS:No single IL-17A polymorphism was associated with premature CAD, however two haplotypes (CAGG and TAGA) were significantly associated with increased risk of premature CAD (OR = 1.35, 95% CI: 1.00-1.84, P = 0.018 and OR = 2.09, 95% CI: 1.16-3.76, P = 0.003, respectively). Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment. CONCLUSION:The results suggest that IL-17A haplotypes are involved in the risk of developing premature CAD and some IL-17A polymorphisms are associated with cardiovascular risk factors in Mexican individuals with premature CAD.http://europepmc.org/articles/PMC4304820?pdf=render |
| spellingShingle | Gilberto Vargas-Alarcón Javier Angeles-Martínez Teresa Villarreal-Molina Edith Alvarez-León Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña Julian Ramírez-Bello Nonanzit Pérez-Hernández Juan Gabriel Juárez-Rojas José Manuel Rodríguez-Pérez José Manuel Fragoso Carlos Posadas-Romero Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. PLoS ONE |
| title | Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. |
| title_full | Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. |
| title_fullStr | Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. |
| title_full_unstemmed | Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. |
| title_short | Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. |
| title_sort | interleukin 17a gene haplotypes are associated with risk of premature coronary artery disease in mexican patients from the genetics of atherosclerotic disease gea study |
| url | http://europepmc.org/articles/PMC4304820?pdf=render |
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