Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases
<i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic infla...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/12/3800 |
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| author | Marta Garcia-Clemente David de la Rosa Luis Máiz Rosa Girón Marina Blanco Casilda Olveira Rafael Canton Miguel Angel Martinez-García |
| author_facet | Marta Garcia-Clemente David de la Rosa Luis Máiz Rosa Girón Marina Blanco Casilda Olveira Rafael Canton Miguel Angel Martinez-García |
| author_sort | Marta Garcia-Clemente |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of <i>P. aeruginosa</i> over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of “hypermutator <i>P. aeruginosa</i> strain”. This phenomenon has been observed in people with bronchiectasis, CF, and the “exacerbator” COPD phenotype. From a clinical point of view, a chronic bronchial infection of <i>P. aeruginosa</i> has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of <i>P. aeruginosa</i> infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review. |
| first_indexed | 2024-03-10T14:36:58Z |
| format | Article |
| id | doaj.art-786d5f5225f34009b958cdaf8e4e7828 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:36:58Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-786d5f5225f34009b958cdaf8e4e78282023-11-20T22:08:34ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01912380010.3390/jcm9123800Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway DiseasesMarta Garcia-Clemente0David de la Rosa1Luis Máiz2Rosa Girón3Marina Blanco4Casilda Olveira5Rafael Canton6Miguel Angel Martinez-García7Pneumology Department, Hospital Universitario Central de Asturias, 33011 Oviedo, SpainPneumology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, SpainServicio de Neumología, Unidad de Fibrosis Quística, Bronquiectasias e Infección Bronquial Crónica, Hospital Ramón y Cajal, 28034 Madrid, SpainPneumology Department, Hospital Univesitario la Princesa, 28006 Madrid, SpainServicio de Neumología, Hospital Universitario A Coruña, 15006 A Coruña, SpainServicio de Neumología, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29010 Málaga, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainPneumology Department, Universitary and Polytechnic La Fe Hospital, 46012 Valencia, Spain<i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of <i>P. aeruginosa</i> over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of “hypermutator <i>P. aeruginosa</i> strain”. This phenomenon has been observed in people with bronchiectasis, CF, and the “exacerbator” COPD phenotype. From a clinical point of view, a chronic bronchial infection of <i>P. aeruginosa</i> has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of <i>P. aeruginosa</i> infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.https://www.mdpi.com/2077-0383/9/12/3800<i>Pseudomonas aeruginosa</i>bronchiectasiscystic fibrosisCOPDasthmachronic bronchial infection |
| spellingShingle | Marta Garcia-Clemente David de la Rosa Luis Máiz Rosa Girón Marina Blanco Casilda Olveira Rafael Canton Miguel Angel Martinez-García Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases Journal of Clinical Medicine <i>Pseudomonas aeruginosa</i> bronchiectasis cystic fibrosis COPD asthma chronic bronchial infection |
| title | Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases |
| title_full | Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases |
| title_fullStr | Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases |
| title_full_unstemmed | Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases |
| title_short | Impact of <i>Pseudomonas aeruginosa</i> Infection on Patients with Chronic Inflammatory Airway Diseases |
| title_sort | impact of i pseudomonas aeruginosa i infection on patients with chronic inflammatory airway diseases |
| topic | <i>Pseudomonas aeruginosa</i> bronchiectasis cystic fibrosis COPD asthma chronic bronchial infection |
| url | https://www.mdpi.com/2077-0383/9/12/3800 |
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