The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study)
Abstract Preterm infants are at a greater risk for the development of asthma and atopic disease, which can lead to lifelong negative health consequences. This may be due, in part, to alterations that occur in the gut microbiome and metabolome during their stay in the Neonatal Intensive Care Unit (NI...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10276-y |
| _version_ | 1818147345952407552 |
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| author | Shiyu S. Bai-Tong Megan S. Thoemmes Kelly C. Weldon Diba Motazavi Jessica Kitsen Shalisa Hansen Annalee Furst Bob Geng Se Jin Song Jack A. Gilbert Lars Bode Pieter C. Dorrestein Rob Knight Sydney A. Leibel Sandra L. Leibel |
| author_facet | Shiyu S. Bai-Tong Megan S. Thoemmes Kelly C. Weldon Diba Motazavi Jessica Kitsen Shalisa Hansen Annalee Furst Bob Geng Se Jin Song Jack A. Gilbert Lars Bode Pieter C. Dorrestein Rob Knight Sydney A. Leibel Sandra L. Leibel |
| author_sort | Shiyu S. Bai-Tong |
| collection | DOAJ |
| description | Abstract Preterm infants are at a greater risk for the development of asthma and atopic disease, which can lead to lifelong negative health consequences. This may be due, in part, to alterations that occur in the gut microbiome and metabolome during their stay in the Neonatal Intensive Care Unit (NICU). To explore the differential roles of family history (i.e., predisposition due to maternal asthma diagnosis) and hospital-related environmental and clinical factors that alter microbial exposures early in life, we considered a unique cohort of preterm infants born ≤ 34 weeks gestational age from two local level III NICUs, as part of the MAP (Microbiome, Atopic disease, and Prematurity) Study. From MAP participants, we chose a sub-cohort of infants whose mothers had a history of asthma and matched gestational age and sex to infants of mothers without a history of asthma diagnosis (control). We performed a prospective, paired metagenomic and metabolomic analysis of stool and milk feed samples collected at birth, 2 weeks, and 6 weeks postnatal age. Although there were clinical factors associated with shifts in the diversity and composition of stool-associated bacterial communities, maternal asthma diagnosis did not play an observable role in shaping the infant gut microbiome during the study period. There were significant differences, however, in the metabolite profile between the maternal asthma and control groups at 6 weeks postnatal age. The most notable changes occurred in the linoleic acid spectral network, which plays a role in inflammatory and immune pathways, suggesting early metabolomic changes in the gut of preterm infants born to mothers with a history of asthma. Our pilot study suggests that a history of maternal asthma alters a preterm infants’ metabolomic pathways in the gut, as early as the first 6 weeks of life. |
| first_indexed | 2024-12-11T12:33:47Z |
| format | Article |
| id | doaj.art-786db184212a4659a573fb5c9e1f597d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-11T12:33:47Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-786db184212a4659a573fb5c9e1f597d2022-12-22T01:07:10ZengNature PortfolioScientific Reports2045-23222022-04-0112111210.1038/s41598-022-10276-yThe impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study)Shiyu S. Bai-Tong0Megan S. Thoemmes1Kelly C. Weldon2Diba Motazavi3Jessica Kitsen4Shalisa Hansen5Annalee Furst6Bob Geng7Se Jin Song8Jack A. Gilbert9Lars Bode10Pieter C. Dorrestein11Rob Knight12Sydney A. Leibel13Sandra L. Leibel14Division of Neonatology, Rady Children’s Hospital, University of California, San DiegoDepartment of Pediatrics and Scripps Institution of Oceanography, University of California, San DiegoCenter for Microbiome Innovation, University of California San DiegoDivision of Allergy and Immunology, Rady Children’s Hospital, University of California, San DiegoDivision of Allergy and Immunology, Rady Children’s Hospital, University of California, San DiegoCenter for Microbiome Innovation, University of California San DiegoDivision of Neonatology, Department of Pediatrics, University of California San DiegoDivision of Allergy and Immunology, Rady Children’s Hospital, University of California, San DiegoCenter for Microbiome Innovation, University of California San DiegoDepartment of Pediatrics and Scripps Institution of Oceanography, University of California, San DiegoDivision of Neonatology, Department of Pediatrics, University of California San DiegoCenter for Microbiome Innovation, University of California San DiegoCenter for Microbiome Innovation, University of California San DiegoDivision of Allergy and Immunology, Rady Children’s Hospital, University of California, San DiegoDivision of Neonatology, Rady Children’s Hospital, University of California, San DiegoAbstract Preterm infants are at a greater risk for the development of asthma and atopic disease, which can lead to lifelong negative health consequences. This may be due, in part, to alterations that occur in the gut microbiome and metabolome during their stay in the Neonatal Intensive Care Unit (NICU). To explore the differential roles of family history (i.e., predisposition due to maternal asthma diagnosis) and hospital-related environmental and clinical factors that alter microbial exposures early in life, we considered a unique cohort of preterm infants born ≤ 34 weeks gestational age from two local level III NICUs, as part of the MAP (Microbiome, Atopic disease, and Prematurity) Study. From MAP participants, we chose a sub-cohort of infants whose mothers had a history of asthma and matched gestational age and sex to infants of mothers without a history of asthma diagnosis (control). We performed a prospective, paired metagenomic and metabolomic analysis of stool and milk feed samples collected at birth, 2 weeks, and 6 weeks postnatal age. Although there were clinical factors associated with shifts in the diversity and composition of stool-associated bacterial communities, maternal asthma diagnosis did not play an observable role in shaping the infant gut microbiome during the study period. There were significant differences, however, in the metabolite profile between the maternal asthma and control groups at 6 weeks postnatal age. The most notable changes occurred in the linoleic acid spectral network, which plays a role in inflammatory and immune pathways, suggesting early metabolomic changes in the gut of preterm infants born to mothers with a history of asthma. Our pilot study suggests that a history of maternal asthma alters a preterm infants’ metabolomic pathways in the gut, as early as the first 6 weeks of life.https://doi.org/10.1038/s41598-022-10276-y |
| spellingShingle | Shiyu S. Bai-Tong Megan S. Thoemmes Kelly C. Weldon Diba Motazavi Jessica Kitsen Shalisa Hansen Annalee Furst Bob Geng Se Jin Song Jack A. Gilbert Lars Bode Pieter C. Dorrestein Rob Knight Sydney A. Leibel Sandra L. Leibel The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study) Scientific Reports |
| title | The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study) |
| title_full | The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study) |
| title_fullStr | The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study) |
| title_full_unstemmed | The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study) |
| title_short | The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study) |
| title_sort | impact of maternal asthma on the preterm infants gut metabolome and microbiome map study |
| url | https://doi.org/10.1038/s41598-022-10276-y |
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